ABO血型与糖尿病发生风险的meta分析

发布时间：2017-12-27 01:25

本文关键词：ABO血型与糖尿病发生风险的meta分析　出处：《第二军医大学学报》2016年03期 　论文类型：期刊论文

【摘要】：目的用meta分析方法研究ABO血型在糖尿病患者和健康人群中的分布情况,以评价ABO血型系统与糖尿病发生风险的关系。方法通过检索PubMed、中国生物医学文献数据库、维普中文科技期刊数据库、中国知网期刊数据库和万方数据库等,收集有关糖尿病与ABO血型系统之间关系的原始文献,按照纳入与排除标准筛选出符合要求的文献并提取出相关的数据,使用NOS量表对纳入文献进行质量评价,采用Review Manager 5.1和Stata 12.0软件进行meta分析。结果 B血型和AB血型在糖尿病患者和对照人群中的分布差异有统计学意义,表现为B血型在糖尿病患者中所占比例高于对照人群(OR=1.13,95%CI:1.05~1.21,P=0.000 7),AB血型则在对照人群中更为常见(OR=0.86,95%CI:0.77~0.97,P=0.01);但亚组分析时发现B血型和AB血型的分布差异仅在国外人群中有统计学意义(P0.05)。而A血型(OR=0.90,95%CI:0.76~1.07,P=0.24)和O血型(OR=1.00,95%CI:0.89~1.13,P=0.96)在两组中的分布差异无统计学意义。结论糖尿病的发生可能与ABO血型有关。国外人群中B血型的糖尿病发病风险高于其他血型,AB血型可能是糖尿病发生的保护因子,而A血型和O血型在国内外人群中与糖尿病的发生均无关。
[Abstract]:Objective to study the distribution of ABO blood type in diabetic patients and healthy population by meta analysis, and to evaluate the relationship between ABO blood group system and the risk of diabetes. Methods by searching PubMed, China biomedical literature database, VIP journals database, Chinese China HowNet periodical database and Wanfang database, the original collection of literature on the relationship between diabetes and ABO blood group system, according to the inclusion and exclusion criteria selected to meet the requirements of the document and extract relevant data, use the NOS scale to evaluate the quality of of the literature, using Review Manager 5.1 and Stata 12 software for meta analysis. There were statistically significant differences in the distribution of B and AB blood type in diabetic patients and controls in the results, performance for B blood group in diabetic patients was higher than that in the control group (OR=1.13,95%CI:1.05~1.21, P=0.000 7), AB blood group in the control group is more common (OR= 0.86,95%CI:0.77~0.97, P=0.01); but the subgroup analysis found the different distribution of B blood group and AB blood group was statistically significant only in the foreign population (P0.05). There was no significant difference in the distribution of A blood group (OR=0.90,95%CI:0.76~1.07, P=0.24) and O blood group (OR=1.00,95%CI:0.89~1.13, P=0.96) in the two groups. Conclusion the occurrence of diabetes may be related to the ABO blood group. The risk of diabetes in group B is higher than that in other blood groups. AB blood group may be a protective factor for diabetes, while A blood group and O blood group are not related to diabetes mellitus at home and abroad.
【作者单位】：重庆医科大学公共卫生与管理学院医学与社会发展研究中心健康领域社会风险预测治理协同创新中心流行病学教研室;
【分类号】：R587.1
【正文快照】： 病。作为全球发病率极高的代谢综合征,糖尿病可以导致很多脏器的功能障碍或衰竭,引起机体损伤,并引发一系列的并发症[1]。相关数据表明,2013年全球糖尿病患者已达到3.82亿人,且预计在2035年时这一数字将变为5.92亿人[2]。近年来,随着社会的不断发展、人们生活方式的转变、饮食

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