低密度脂蛋白胆固醇与跟腱厚度相关性的初步临床研究

发布时间：2017-12-28 00:24

  本文关键词：低密度脂蛋白胆固醇与跟腱厚度相关性的初步临床研究　出处：《中国循环杂志》2016年02期 　论文类型：期刊论文

  更多相关文章： 脂蛋白类 LDL 跟腱 黄瘤病 放射摄影术

【摘要】：目的:研究血清低密度脂蛋白胆固醇(LDL-C)水平与跟腱厚度(ATT)之间的相关性。方法:2014-03至2015-03期间收集18~75岁、血清LDL-C水平高于正常上限(≥3.37 mmol/L)的患者154例,根据《中国成人血脂异常防治指南(2007年)》,分为LDL-C边缘升高(3.37~4.12 mmol/L)组(n=50)和LDL-C升高(≥4.14 mmol/L)组(n=104);另以血清LDL-C水平正常(3.37 mmol/L)者作为对照组(n=51)。采用标准化的直接数字化X线摄影术测量三组受试者的ATT,进行比较,并分析血清LDL-C水平与ATT之间的相关性。结果:LDL-C升高组的ATT平均值[(9.42±3.63)mm]高于LDL-C边缘升高组[(8.24±1.73)mm]和对照组[(6.05±0.28)mm],三组受试者ATT间的差异均具有统计学意义(P均0.05)。线性相关分析显示,血清LDL-C水平与ATT平均值的相关系数r=0.346(P0.001)。结论:本研究小样本初步观察发现,血清LDL-C水平越高,ATT越厚,血清LDL-C水平与ATT呈正相关,该现象及其意义有待大样本多中心研究进一步证实。
[Abstract]:Objective: To study the correlation between serum low density lipoprotein cholesterol (LDL-C) level and the thickness of Achilles tendon (ATT). Methods: 2014-03 and 2015-03 were collected during the 18~75 years of age, the serum level of LDL-C was higher than the normal limit (mmol/L = 3.37) of 154 cases of patients, according to the "China adult dyslipidemia prevention guide" (2007), divided into the edge of the LDL-C (3.37~4.12 mmol/L) group increased (n=50) and LDL-C (high rise more than 4.14 mmol/L (n=104 group)); the other to normal level of serum LDL-C (3.37 mmol/L) as control group (n=51). The ATT of three groups of subjects was measured by standardized direct digital radiography, and the correlation between serum LDL-C level and ATT was analyzed. Results: the mean value of ATT in LDL-C increased group [(9.42 + 3.63) mm] was higher than that in LDL-C marginal elevation Group [(8.24 + 1.73) mm] and control group [(6.05 + 0.28) mm], three groups of subjects had significant differences in ATT (P all 0.05). Linear correlation analysis showed that the correlation coefficient of serum LDL-C level and the mean value of ATT was r=0.346 (P0.001). Conclusion: the small sample preliminary observation shows that the higher serum LDL-C level and the thicker the ATT is, the positive correlation is found between serum LDL-C level and ATT. This phenomenon and its significance need further confirmation by large sample and multicenter study.
【作者单位】： 海南省农垦三亚医院心内科;广州医科大学研究生学院;海南省农垦三亚医院放射科;海南省农垦三亚医院检验科;
【基金】：海南省医药卫生科研项目(1421320.24A1005)
【分类号】：R589.2
【正文快照】： 血清胆固醇水平升高会导致皮肤和肌腱黄色korotkoff第Ⅰ音和第Ⅴ音作为收缩压(SBP)、舒张瘤的出现[1],这种表现在家族性高胆固醇血症(FH)压(DBP),间隔1~2 min重复测量,取2次读数的患者中尤为明显[2-4]。跟腱作为全身最厚最强壮的平均值记录。如果SBP或DBP的2次读数相差5肌腱[5，

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