老年2型糖尿病患者5种血清肿瘤标志物的表达及影响因素分析

发布时间：2018-01-01 11:01

本文关键词：老年2型糖尿病患者5种血清肿瘤标志物的表达及影响因素分析　出处：《上海交通大学学报(医学版)》2016年07期 　论文类型：期刊论文

【摘要】：目的分析老年2型糖尿病患者血清肿瘤标志物CA199、CEA、CA153、CA125、AFP的水平及其影响因素。方法收集2012年6月—2014年7月收治的老年2型糖尿病患者[糖尿病组,平均年龄(61.53±4.95)岁,n=241]的资料,以年龄匹配的同时期接受健康体检者的资料作为对照(对照组,n=178)。比较2组5种血清肿瘤标志物水平。根据糖化血红蛋白水平和年龄将糖尿病组患者进行再分组,比较各组患者血清肿瘤标志物水平;利用Pearson相关分析和多因素Logistic回归分析相关影响因素。结果糖尿病组患者血清CA199、CEA、CA153水平明显高于对照组(P0.05)。不同糖化血红蛋白水平组的血清CA199、CEA表达水平的差异有统计学意义(P0.05);不同年龄组的血清CA199、CEA和CA153水平的差异有统计学意义(P0.05)。Logistic回归分析结果显示:BMI升高、血白蛋白水平降低是血清CA199水平升高的危险因素;年龄增大是血清CEA、CA153水平升高的危险因素;血肌酐水平升高、血白蛋白水平下降是血清CA125水平升高的危险因素。结论老年2型糖尿病患者部分血清肿瘤标志物水平升高,临床判读时应结合其糖化血红蛋白水平、年龄等因素综合考虑,长期随访,以免误诊和漏诊。
[Abstract]:Objective to analyze the elderly patients with type 2 diabetes serum markers CA199, CEA, CA153, CA125, AFP level and its influence factors. Methods from June 2012 to July 2014 were elderly patients with type 2 diabetes mellitus [diabetic group, the average age (61.53 + 4.95) years old, material n=241], age matching and health the physical examination as control (control group, n=178). Compared with 2 groups of 5 serum tumor markers level. Then grouped according to HbA1c levels and age of diabetes patients, compare the levels of serum levels of tumor markers; using Pearson correlation analysis and multivariate Logistic regression analysis of related factors. The diabetes group serum CA199, CEA, CA153 was significantly higher than control group (P0.05). Serum CA199 different glycosylated hemoglobin level group, there were statistically significant differences in the expression level of CEA (P0.05); not The serum CA199 of the same age group, there was statistically significant difference between the CEA and CA153 level (P0.05) and.Logistic regression analysis showed that the increase of BMI, lower serum albumin level were risk factors of elevated serum CA199 levels; age is the risk factors of serum CEA, CA153 levels increased; elevated serum creatinine level, serum albumin level is decreased the risk factors of elevated serum CA125 levels. Conclusion the serum tumor markers in elderly patients with type 2 diabetes increased the level of clinical interpretation should be combined with the glycated hemoglobin level, long-term follow-up comprehensive consideration of factors such as age, in order to avoid misdiagnosis and missed diagnosis.

【作者单位】：复旦大学附属华东医院内分泌科;复旦大学附属华东医院肿瘤科;
【分类号】：R587.1
【正文快照】： 近年来,随着经济的发展,工业化进程的加速,人类生存环境及生活方式的不断改变,恶性肿瘤的发生率及病死率呈明显上升趋势。肿瘤标志物对肿瘤的筛查、诊断、疗效观察、监测复发以及预后评价具有重要价值,是恶性肿瘤常用的筛查手段[1]。临床实践发现,部分老年2型糖尿病患者的血清

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