初诊断Graves病患者白细胞或中性粒细胞减少与TRAb相关性研究

发布时间：2018-01-03 05:29

本文关键词：初诊断Graves病患者白细胞或中性粒细胞减少与TRAb相关性研究　出处：《免疫学杂志》2016年07期 　论文类型：期刊论文

【摘要】：目的探讨初诊断Graves病患者白细胞或中性粒细胞减少的相关因素及其与TRAb水平的相关性。方法选取初诊断Graves病患者336例,根据白细胞及中性粒细胞水平分组,238例白细胞和中性粒细胞正常者为对照组(A组),98例白细胞或中性粒细胞减少者为研究组(B组)。比较并分析2组患者的一般情况及实验室检查特征。结果 B组TRAb水平显著高于A组(18.09±13.29 vs 13.75±12.9,P0.05),而甲功、TGAb、TPOAb无统计学差异。回归分析表明,Graves病甲亢患者合并白细胞或中性粒细胞减少的风险女性大于男性(P0.05)。Graves病甲亢患者TRAb水平越高,合并白细胞或中性粒细胞减少的风险越大(OR=1.025,95%CI=1.005~1.046,P=0.014)。Graves病甲亢患者白细胞计数(r=-0.024,P=0.001)、中性粒细胞计数(r=-0.018,P=0.003)与TRAb水平呈负相关。结论初诊断Graves病患者白细胞或中性粒细胞减少与TRAb水平相关。
[Abstract]:Objective to investigate the correlation between leukocyte or neutropenia and TRAb level in patients with Graves disease. Methods 336 patients with Graves disease were selected. According to the level of leukocyte and neutrophil, 238 cases of normal leukocytes and neutrophils were divided into control group (group A). 98 cases of leukopenia or neutropenia in study group B were compared and analyzed. Results the level of TRAb in group B was significantly higher than that in group A (P < 0.05). 18.09 卤13.29 vs 13.75 卤12.9. There was no significant difference in TGAb-TPOAb between two groups. Regression analysis showed that there was no significant difference in TGAb-TPOAb between the two groups. The higher the risk of leukocyte or neutropenia in patients with hyperthyroidism with Graves's disease, the higher the TRAb levels in women than in men with hyperthyroidism. The greater the risk of leukopenia or neutrophil reduction, the greater the risk of OR1. 025 + 95 CIQ 1. 005 and 1. 046. The leukocyte count of patients with hyperthyroidism and neutrophil count were r ~ 0. 014 ~ 0. 018 and 0. 024 ~ 0. 001 ~ 0. 001g respectively. Conclusion WBC or neutropenia is correlated with TRAb level in patients with Graves disease.
【作者单位】：无锡市中医医院(南京中医药大学无锡附属医院)内分泌科;
【基金】：无锡市卫生局面上科研项目(MS201519) 江苏省中医药局科技项目(YB2015077)
【分类号】：R581.1
【正文快照】： Graves病是自身免疫性甲状腺疾病,其促甲状腺激素受体(TSHR)抗体(TRAb)刺激促甲状腺激素受体(TSHR),导致甲状腺激素过量表达和毒性弥漫性甲状腺肿大[1-2],可累及全身多个器官,其中以血液系统受损最为常见,常表现为白细胞和粒细胞减少。具体发病机制目前尚不明确,Graves病甲亢

【相似文献】