绝经后骨质疏松患者体质指数、骨转换指标与骨密度和骨折的相关性

发布时间：2018-01-04 08:03

本文关键词：绝经后骨质疏松患者体质指数、骨转换指标与骨密度和骨折的相关性　出处：《中国老年学杂志》2016年01期 　论文类型：期刊论文

【摘要】：目的探讨绝经后骨质疏松(POP)患者骨转换指标、体质指标与骨密度(BMD)和骨折的相关性。方法选择78例48~74岁POP妇女,用双能X线吸收法(DEXA)测定腰椎L_(1~4)(正位)、股骨颈及髋部BMD,测量患者身高、体重,计算体重指数(BMI)。采集空腹血后测定血清Ⅰ型胶原氨基端前肽(PINP)、Ⅰ型胶原羧基末端肽(CTX)、甲状旁腺激素(PTH)、碱性磷酸酶(ALP)。结果 1年龄与CTX、ALP、身高和BMI存在明显相关性,相关系数(r)分别为0.302、0.334、-0.229和0.325。2年龄与腰椎、股骨颈及髋部BMD间均存在负相关,r分别为-0.280、-0.364和-0.390。3校正年龄因素影响后,PINP与股骨颈和髋部BMD间存在负相关,r分别为-0.434和-0.304;ALP与股骨颈BMD存在负相关,r为-0.209。4脆性骨折组腰椎BMD、体重和BMI较无骨折组都有非常显著的差异。5脆性股骨颈骨折组PINP和ALP均显著高于无骨折组、脆性非股骨颈骨折组。结论年龄是影响BMI、BMD和骨转换指标的重要因素,骨转换指标和BMD间存在负相关。肥胖、腰椎BMD降低及PINP和ALP等骨转换指标的升高都可增加POP患者发生脆性骨折的风险。
[Abstract]:Objective to investigate the postmenopausal osteoporosis (POP) in patients with bone transfer index, index and bone mineral density (BMD) and physical fracture correlation. Methods 78 cases of 48~74 years old women with POP, using dual energy X-ray absorptiometry (DEXA) determination of lumbar L_ (1~4) (anteroposterior), femoral neck and hip BMD, measurement patient height, weight, body mass index (BMI). Fasting blood collection after the determination of serum type I collagen amino terminal propeptide (PINP), type I collagen carboxy terminal peptide (CTX), parathyroid hormone (PTH), alkaline phosphatase (ALP). The results of 1 age and CTX, ALP, and BMI have obvious height correlation, correlation coefficient (R) were 0.302,0.334, -0.229 and 0.325.2 and the age of the lumbar spine, femoral neck and hip BMD were negatively related to R and -0.280 respectively, and the effect of -0.364 -0.390.3 after adjustment for age, there is a negative correlation between PINP and femoral neck and hip between BMD, R and -0.304 were -0.434 and ALP; femoral neck BMD negatively R -0.209.4, the brittle fracture group of lumbar BMD, weight and BMI compared with no fracture group are PINP and ALP between.5 group of femoral neck fracture was brittle fracture group were significantly higher than that of non, non brittle fracture of the femoral neck group. Conclusion age is the important factor affecting BMI, BMD and bone turnover markers, there is a negative correlation between BMD and bone turnover markers. Obesity, lumbar BMD and reduction of PINP and ALP increased bone turnover may increase POP risk in patients with fracture.

【作者单位】：天津医院检验科;
【基金】：天津市卫生局课题(2011KY27)
【分类号】：R580
【正文快照】： 绝经后骨质疏松(POP)又称原发性Ⅰ型骨质疏松(OP),常见于50~70岁的女性。OP的严重后果为OP性骨折,其中髋部骨折是OP引起的最严重后果,高达50%的患者会遗留长期的不可恢复的行动障碍〔1〕。因此早期预测OP的骨折危险性很必要。骨密度(BMD)虽然可以诊断OP,但不能及时反映受试者

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