麝香乌龙丸联合来氟米特片治疗寒湿痹阻型类风湿关节炎59例临床观察

发布时间：2018-01-04 13:12

本文关键词：麝香乌龙丸联合来氟米特片治疗寒湿痹阻型类风湿关节炎59例临床观察　出处：《中医杂志》2016年19期 　论文类型：期刊论文

【摘要】：目的观察麝香乌龙丸治疗类风湿关节炎患者的临床疗效及安全性。方法将114例类风湿关节炎患者随机分为治疗组59例与对照组55例,两组患者均口服来氟米特片,每次10 mg,每日2次。治疗组在此基础上加用麝香乌龙丸,每次3 g,每日2次;对照组加服白芍总苷胶囊,每次0.6 g,每日3次;两组均治疗2个月。比较两组临床疗效,并观察治疗前及治疗后1、2个月两组肿胀关节数、压痛关节数、晨僵时间、中医证候积分、疼痛指数以及类风湿因子(RF)、血沉(ESR)、C反应蛋白(CRP)、抗环瓜氨酸肽抗体(抗CCP抗体)变化,并记录不良反应。结果治疗组总有效率为91.53%,对照组总有效率89.09%,两组疗效等级的构成比差异有统计学意义(P0.05),治疗组优于对照组。治疗1个月后两组患者的肿胀关节数、压痛关节数、晨僵时间、中医证候积分、疼痛指数和患者对病情的整体评估均较治疗前明显降低(P0.05),治疗2个月后两组的上述指标均较治疗前、治疗1个月后时明显降低(P0.05)。治疗1个月治疗组肿胀关节数、压痛关节数、中医证候积分、疼痛指数、患者对病情的整体评估改善情况均优于对照组(P0.05)。治疗2个月后治疗组患者的压痛关节数、中医证候积分、疼痛指数、患者对病情的整体评估改善情况优于对照组,对照组的晨僵时间改善情况优于治疗组(均P0.05);治疗后两组肿胀关节数及RF、ESR、CRP和抗CCP抗体比较差异均无统计学意义(P0.05)。两组患者均未出现严重不良反应。结论麝香乌龙丸能迅速缓解类风湿关节炎患者的急性症状,临床疗效确切,安全性高。
[Abstract]:Objective to observe the clinical efficacy and safety of Shexiang Wulong pills in treating rheumatoid arthritis. Methods 114 patients with rheumatoid arthritis were randomly divided into treatment group (59 cases) and control group (55 cases). The patients in both groups were given leflunomide tablets 10 mg twice a day. The treatment group was treated with Shexiang Wulong pills 3 g each time twice a day. The control group was treated with total glucoside of paeony, 0.6 g each time, 3 times a day. The two groups were treated for 2 months. Compared the clinical efficacy of the two groups, and observed the number of swollen joints, tenderness joints, morning stiffness time, TCM syndromes score before treatment and 1, 2 months after treatment. The changes of pain index and rheumatoid factor (RF), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), anti-cyclic citrullinated peptide antibody (CCP antibody) were observed. Results the total effective rate was 91.53 in the treatment group and 89.09 in the control group. The treatment group was superior to the control group. After one month treatment, the number of swollen joints, the number of tenderness joints, the time of morning stiffness, the integral of TCM syndromes in the two groups were better than those in the control group. The pain index and the overall assessment of the patient's condition were significantly lower than that before treatment, and the above indexes in the two groups were higher than those before treatment 2 months after treatment. After 1 month treatment, the number of swollen joints, tenderness joints, TCM syndrome scores and pain index were significantly decreased in the treatment group. After 2 months of treatment, the number of tenderness joints, TCM syndromes integral, and pain index of the patients in the treatment group were better than those in the control group (P 0.05). The overall evaluation and improvement of the patients' condition was better than that of the control group, and the improvement of morning stiffness time in the control group was better than that in the treatment group (all P 0.05). After treatment, the number of swollen joints and the ESR of RFU were observed in both groups. There was no significant difference in CRP and anti CCP antibody between the two groups. There were no serious adverse reactions in the two groups. Conclusion Shexiang Wulong pills can relieve the acute symptoms of rheumatoid arthritis patients quickly. The clinical curative effect is accurate, the safety is high.
【作者单位】：华北理工大学中医学院;华北理工大学附属医院;
【基金】：河北省中医药管理局省级中医药类重大医学科研项目(zyzd2013017)
【分类号】：R593.22
【正文快照】： 类风湿关节炎(rheumatoid arthritis,RA)是一种病因未明的累及多脏器、多系统的自身免疫性疾病,失治、误治均可使患者的病情迁延难愈,最终造成关节的功能障碍,为临床常见的难治性疾病。中成药以其不良反应少、安全性高且可以减轻西药的毒副作用而被临床广泛应用。本研究旨在观

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