糖尿病性耳聋听力变化特点

发布时间：2018-01-05 18:02

  本文关键词：糖尿病性耳聋听力变化特点　出处：《中华耳科学杂志》2016年06期 　论文类型：期刊论文

  更多相关文章： ZDF鼠 Ⅱ型糖尿病 耳聋 听力减退

【摘要】：目的探讨自发性糖尿病鼠初期听力变化特点。方法清洁级雄性,7周龄Zucker Diabetes Fat(ZDF)大鼠根据糖尿病发病与否分发生糖尿病的ZDF模型鼠(fa/fa)为实验组10只,不发生糖尿病的ZDF对照鼠(fa/+)为对照组5只。分别于2、3、4、5、6月大小时测大鼠的体重、空腹血糖、短声诱发听性脑干反应(Click-ABR)、短纯音诱发听性脑干反应(tb-ABR)、畸变产物耳声发射(DPOAEs)。结果实验鼠在第2月龄内12小时禁食不禁饮测空腹血糖在正常范围,第3月龄时实验鼠的空腹血糖已达糖尿病标准并维持在较高水平;对照组大鼠血糖一直保持在正常范围。根据测得空腹血糖值大小实验组空腹血糖值上升相对较快的鼠(实验组H)在4月龄时tb-ABR在8k Hz上的阈值较其2月龄时阈值升高(P0.05);Click-ABR 90d BSPLⅠ波潜伏期、Ⅰ-Ⅲ间期较在2月龄时延长(P0.05),4月后Ⅰ波潜伏期、Ⅰ-Ⅲ间期开始缩短。实验组空腹血糖上升相对较慢鼠(实验组L)在5月龄时tb-ABR在8k Hz、16k Hz、32k Hz的阈值较2月龄时阈值升高(P0.05),以32k Hz听力损失最严重,Click-ABR90d BSPLⅠ波及Ⅰ-Ⅲ波潜伏期出现较明显延长(P0.05),5月后Ⅰ波潜伏期、Ⅰ-Ⅲ间期开始缩短。对照组大鼠实验前后听力无变化(P0.05)。结论肥胖ZDF糖尿病大鼠发病前期听力无明显变化,糖尿病鼠发病稳定后1到2个月(即4、5月龄)开始出现较明显的听力损害;糖尿病听力损失的发病进展速度也许与血糖升高的快慢有关;糖尿病鼠高频听力损失较重,提示临床糖尿病人应当监测高频听力变化。
[Abstract]:Objective to investigate the characteristics of primary hearing changes in spontaneously diabetic rats. The 7-week-old ZDF rats with diabetes mellitus were divided into 10 experimental groups (n = 10). Five ZDF control rats without diabetes were used as control group. The body weight and fasting blood glucose were measured on June. Short tone evoked auditory brainstem response (Click-ABRN), short pure tone evoked auditory brainstem response (Tb-ABR). Results the rats fasted for 12 hours during the second month, and the fasting blood glucose was measured in the normal range. At the third month, the fasting blood glucose of the rats reached the diabetic standard and maintained at a higher level. The blood glucose in the control group remained in the normal range. According to the level of fasting blood glucose measured, the fasting blood glucose level of the experimental group increased relatively quickly (experimental group H). The threshold value of tb-ABR at 8kHz at 4 months old was higher than that at 2 months old. The latencies of BSPL wave 鈪，

本文编号：1384209