糖尿病肾病治疗中益肾化湿颗粒与贝那普利联合应用的价值分析

发布时间：2018-01-13 06:33

本文关键词：糖尿病肾病治疗中益肾化湿颗粒与贝那普利联合应用的价值分析　出处：《辽宁中医杂志》2016年01期 　论文类型：期刊论文

【摘要】：目的:总结联合益肾化湿颗粒及贝那普利治疗糖尿病肾病(DN)的临床应用价值。方法:以随机数字表法将80例DN患者随机分为两组,每组40例。以在常规降糖的同时接受贝那普利治疗者为对照组,以在常规降糖的同时接受联合益肾化湿颗粒及贝那普利治疗者为观察组。对比两组接受治疗后的临床治疗效果。结果:两组入组时FPG、2h BG、Cr、BUN及24 hm Alb水平比较,未见统计学差异(P0.05),而在接受治疗4周后,观察组FPG、2 h BG、Cr、BUN及24 hm Alb水平明显低于对照组(P0.05)。对照组治疗总有效率为70.00%,观察组治疗总有效率为90.00%,观察组治疗总有效率明显高于对照组(P0.05)。两组治疗期间副作用发生率比较,无统计学差异(P0.05)。结论:DN治疗中联合益肾化湿颗粒及贝那普利可在不降低患者治疗效果的同时,有效的通过临床治疗效果。
[Abstract]:Objective: to summarize the clinical application value of combined therapy of kidney tonifying wet granule and benazepril in the treatment of diabetic nephropathy. Methods: 80 patients with DN were randomly divided into two groups by random digital table. 40 patients in each group were treated with benazepril as control group. The observation group was treated with the combination of Yishen Huashi granule and benazepril. The clinical effects of the two groups were compared after the treatment. Results: the two groups were treated with FPG2 h BGN Cr. There was no statistical difference between BUN and 24 hm Alb, but after 4 weeks of treatment, the observation group had 2 h BGG cr. The levels of BUN and 24hm Alb were significantly lower than those of the control group (P 0.05). The total effective rate of the control group was 70. 00 and the total effective rate of the observation group was 90.00%. The total effective rate in the observation group was significantly higher than that in the control group (P 0.05). There was no statistical difference (P 0.05). Conclusion the combination of Yishen Huashi granule and benazepril in the treatment of the patients with DN can effectively pass through the clinical treatment while not reducing the therapeutic effect of the patients.
【作者单位】：华北理工大学基础医学院组织胚胎学系;华北理工大学附属医院肾内科;
【基金】：河北省卫生厅科研基金项目(20130375) 唐山市科技计划项目(13130259z)
【分类号】：R587.2
【正文快照】： 糖尿病肾病(diabetic nephropathy,DN)是糖尿病最为严重的慢性并发症之一,其是因糖尿病所引发的糖代谢异常,代谢产物过多的沉积于肾小管所致[1-2]。本病病发后可导致患者体内的多种炎性因子大量的释放,进一步加重糖尿病病情,可显著的降低患者的临床预后[3-4]。虽然目前医学技

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