ADAM33基因S1和S2多态性与哮喘易感性关联的Meta分析

发布时间：2018-01-13 08:07

  本文关键词：ADAM33基因S1和S2多态性与哮喘易感性关联的Meta分析　出处：《中国老年学杂志》2016年04期 　论文类型：期刊论文

  更多相关文章： ADAM 哮喘 基因多态性

【摘要】：目的探讨整合素和金属蛋白酶域33(ADAM33)基因S1(rs3918396 GA)和S2(rs528557 GC)多态性与哮喘易感性的相关性。方法检索CBM、维普、万方、CNKI、Pub Med、Embase、Google学术、Web of Science等电子数据库,检索范围从建库至2013年8月,采用STATA 12.0软件计算优势比(OR)及其95%可信区间(95%CI)。结果共计纳入10项病例对照研究,包括5 777例哮喘患者和6 800例健康对照人群。Meta分析结果表明:ADAM33基因S2多态性与哮喘易感性增加有关(G vs.C:OR=1.17,95%CI:1.10~1.24,P0.001;GG+GC vs.CC:OR=1.35,95%CI:1.20~1.53,P0.001),但S1多态性与哮喘易感性无明确统计学关联(G vs.A:OR=0.92,95%CI:0.71~1.18,P=0.502;GG+GC vs.CC:OR=0.76,95%CI:0.45~1.27,P=0.295)。根据种族不同进行亚组分析发现,ADAM33基因S2多态性与亚洲人群和欧美人群哮喘易感性增加均有关联(P均0.05)。然而ADAM33基因S1多态性与不同种族人群哮喘易感性均无显著关联(均P0.05)。结论 ADAM33 S2多态性可能与哮喘易感性增加有关,它可以作为早期诊断哮喘的重要分子标志物。
[Abstract]:Objective to investigate the expression of integrin and metalloproteinase domain 33 (ADAM33) gene S1 rs3918396) and S2 rs528557 GC). The association between polymorphism and susceptibility to asthma. Methods CBM was searched. Weip, CNKI, Pub Medbase, Google academic Web of Science and other electronic databases. The search ranges from the construction of the database to August 2013. STATA 12.0 software was used to calculate the odds ratio (OR) and its 95% confidence interval (95% CI). The results were included in 10 case-control studies. A meta-analysis of 5 777 asthmatic patients and 6 800 healthy controls showed that the S2 polymorphism of the 1: ADAM33 gene was associated with increased susceptibility to asthma. G vs.C:OR=1.17. 95 CI: 1.10 and 1.24 P0.001; GG GC vs.CC: 1.35 and 95 CI: 1.20 1.53 P0.001). However, there was no statistical correlation between S1 polymorphism and asthma susceptibility. GG GC vs.CC: 0.76 / 95 CI: 0.45 / 1.27 / 0.295.The subgroup analysis was conducted according to race. S2 polymorphism of ADAM33 gene was associated with increased susceptibility to asthma in Asian and European populations (P < 0.05). However, there was no significant association between S1 polymorphism of ADAM33 gene and susceptibility to asthma in different ethnic groups (all P 0.05). Conclusion ADAM33 S2 polymorphism may be associated with increased susceptibility to asthma. It can be used as an important molecular marker for early diagnosis of asthma.
【作者单位】： 大连医科大学附属第一医院;大连大学附属中山医院;
【分类号】：R562.25
【正文快照】： 1大连大学附属中山医院支气管哮喘是一种由多种细胞因子、炎性介质参与的气道变应性炎症,主要以肥大细胞、T淋巴细胞浸润以及嗜酸性粒细胞为特征〔1〕。患者气道高反应性主要由慢性炎症引起,在临床上主要表现为反复发作的喘息、气促、咳嗽或胸憋等症状,病情多在清晨和夜间加剧，

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