正清风痛宁联合化学药物治疗类风湿关节炎随机对照试验的系统评价

发布时间：2018-01-26 19:25

本文关键词： 正清风痛宁联合用药类风湿关节炎随机对照试验系统评价　出处：《中国实验方剂学杂志》2016年16期 　论文类型：期刊论文

【摘要】：目的:系统评估正清风痛宁联合化学药物治疗类风湿关节炎(rheumatoid arthritis,RA)的有效性及安全性。方法:全面检索CNKI相关期刊论文,维普中文科技期刊全文数据库,万方医药期刊数据库,Sino Med,Pub Med等数据库中正清风痛宁联合化学药物治疗RA的临床随机对照试验研究文献,同时手工检索相关杂志。按Cochrane评价员手册5.1.0评价符合纳入标准的文献质量,采用Review Manger 5.3.5软件进行统计分析。结果:最终共纳入8个随机对照试验,共708例研究对象。结果显示,正清风痛宁联合化学药物治疗RA的总疗效优于单独使用化学药物(Z=3.64,P=0.0003);对晨僵[MD=-13.29,95%CI(-24.66,-1.92),P=0.02]及关节压痛指数[MD=-0.94,95%CI(-1.82,-0.07),P=0.03]改善效果优于单独使用化学药物;正清风痛宁联合组不良反应发生率显著低于单独使用化学药物(P0.000 01)。结论:当前循证证据显示,正清风痛宁联合化学药物治疗RA不仅可以提高化学药物的临床疗效,而且可以显著地降低化学药物的不良反应发生率。受纳入研究文献数量和质量限制,尚需要进一步开展多中心、大样本、双盲、双模拟的高质量临床随机对照试验,以系统评价正清风痛宁联合化学药物治疗RA的有效性及安全性。
[Abstract]:Objective: to evaluate the effect of Zhengqing Fengtongning combined with chemical drugs on rheumatoid arthritis in rheumatoid arthritis. Methods: the full text database of CNKI Chinese periodicals, the full text database of Weipu Chinese scientific and technological journals and the Sino Med database of Wanfang medical journals were searched. Literature on clinical randomized controlled trial of Zhengqing Fengtongning combined with chemical drugs in Pub Med database for RA. At the same time, the relevant journals were searched by hand. According to the Cochrane evaluator's manual 5.1.0, the literature quality was evaluated according to the inclusion criteria. Review Manger 5.3.5 software was used for statistical analysis. Results: a total of 708 subjects were included in 8 randomized controlled trials. The total curative effect of Zhengqing Fengtongning combined with chemical drugs in the treatment of RA was better than that in the treatment of RA by using the chemical drug ZH3.64OP0. 0003; Morning stiffness. [MD-13.2995: CIQ -24.66 ~ -1.92P ~ (0.02) and joint tenderness index. [The improvement effect of MD-0.94 ~ 95C ~ (-1.82) -0.07 ~ (-0.03) was better than that of using chemical drugs alone. The incidence of adverse reactions in Zhengqing Fengtongning combination group was significantly lower than that in chemical drug P0.00001 alone. Conclusion: the current evidence-based evidence shows. Zhengqing Fengtongning combined with chemical drugs can not only improve the clinical efficacy of chemical drugs, but also significantly reduce the incidence of adverse reactions of chemical drugs. There is a need to further develop a multicenter, large sample, double-blind, double-simulated randomized controlled trial of high quality clinical trials to systematically evaluate the efficacy and safety of Zhengqing Fengtongning combined with chemical drugs in the treatment of RA.
【作者单位】：湖南中医药大学中医诊断学湖南省重点实验室药学院;湖南中医药大学附属第一医院;
【基金】：国家自然科学基金项目(81373540) 湖南省战略性新兴产业科技攻关类重大核心技术类项目(2014GK1058) 湖南省中医药科研计划项目(201308) 湖南省研究生科研创新项目(CX2014B362)
【分类号】：R593.22
【正文快照】： 类风湿关节炎(rheumatoid arthritis,RA)是以非化脓性、增生性滑膜炎、侵袭性关节炎为主要临床特点的慢性、炎症性自身免疫性疾病[1]。RA发病机制纷繁复杂,病程缠绵,呈活动期与缓解期交替特征,最终导致不可逆的关节畸形和活动能力丧失[2]。减轻患者疼痛、延缓骨质破坏,保护关

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