不同糖代谢异常老年人血清Irisin水平比较的研究

发布时间：2018-02-01 17:10

本文关键词： 老年人 Irisin 糖尿病型　出处：《中国糖尿病杂志》2017年12期 　论文类型：期刊论文

【摘要】：目的探讨不同糖代谢异常老年人血清Irisin(Iris)水平的差异及影响血清Iris水平的因素。方法随机选取2015年10月至2016年10月于郑州大学第一附属医院老年内分泌科及内分泌科就诊的年龄≥60岁的患者104例,其中,T2DM患者34例,IGT患者36例,IFG患者34例,另选同期体检中心健康体检者36名为对照(NGT)组。研究对象均测量身高、体重、WC、臀围,计算BMI、WHR,检测FIns、2hIns、HbA1c、血清Iris水平等。Pearson相关分析检测血清Iris水平与各指标的相关性。多元线性回归分析Iris水平的影响因素。结果与NGT组比较,IGT组、IFG组、T2DM组血清Iris水平降低[(3.13±2.76)vs(2.79±1.67)vs(2.35±2.69)vs(1.67±1.62)ng/L,F=33.24,P0.05],T2DM组血清Iris水平低于IGT组、IFG组(P0.05),IGT组与IFG组血清Iris水平比较,差异均无统计学意义(P0.05);与NGT组比较,IGT组、IFG组、T2DM组BMI、WHR、HbA1c、TC、TG、LDL-C、eGFR均升高(P0.05),2hIns降低(P0.05),T2DM组、IGT组、IFG组BMI、WHR、TC、TG、LDL-C、eGFR、HbA1c、2hIns差异均无统计学意义(P0.05)。Pearson相关分析显示,T2DM组血清Iris水平与BMI、WHR、TC、TG、LDL-C、HbA1c呈负相关(r=-0.31、-0.29、-0.255、-0.238、-0.352,P0.05),与eGFR呈正相关(r=0.082,P0.05)。多元线性回归分析发现,WHR、HbA1c是血清Iris水平的主要影响因子(β=-3.25、-1.54,P0.05),进一步校正HbA1c后,WHR升高是血清Iris水平下降的独立危险因素。结论 Iris在NGT组、IGT组、IFG组、T2DM组血清中的表达呈逐渐下降趋势,WHR、HbA1c是影响血清Iris水平的重要负性影响因素。
[Abstract]:Objective to study the serum Irisin Irisin of the elderly with different glucose metabolism abnormalities. Methods the age from October 2015 to October 2016 in Department of Endocrinology and Endocrinology in the first affiliated Hospital of Zhengzhou University was randomly selected. 104 cases were over 60 years old. 34 patients with T2DM with IGT and 34 patients with IFG were selected as control group. Height and weight were measured. WC, hip circumference, calculate BMIH WHR, detect FInsn 2h Insn HbA1c. Pearson correlation analysis of serum Iris level was used to detect the correlation between serum Iris level and each index. Multiple linear regression analysis was used to analyze the influencing factors of Iris level. The results were compared with those in NGT group. The level of serum Iris in IGT group is lower than that in T2DM group. [3.13 卤2.76 卤2.79 卤1.67 卤2.35 卤2.69 ng / L 1.67 卤1.62ng / L (P 0.05). The level of serum Iris in T2DM group was lower than that in IGT group (P 0.05). There was no significant difference in serum Iris level between IFG group and T2DM group. Compared with the NGT group, the LDL-CfGFR of the TGG group was significantly higher than that of the T2DM group (P0.05). 2hIns decreased the level of HbA1c in the IGT group and the IFG group. There was no significant difference in 2hIns between serum Iris levels and TGG LDL-C levels in T2DM group. There was a negative correlation between HbA1c and eGFR. Multiple linear regression analysis showed that HbA1c was the main influencing factor of serum Iris level (尾 -3.25- 1.54 P0.05). The increase of serum Iris level is an independent risk factor for the decrease of serum Iris level after further correction of HbA1c. Conclusion Iris is a risk factor in NGT group. The expression of HbA1c in serum of T2DM group showed a decreasing trend. WHRG-HbA1c was an important negative factor affecting serum Iris level.
【作者单位】：郑州大学第一附属医院老年内分泌科;
【基金】：河南省卫生科技创新型人才工程基金资助项目(4111) 河南省卫生科技攻关项目(201602076)
【分类号】：R587.1
【正文快照】： 我国2007~2008年全国糖尿病调查报告数据显示,60岁以上老年人糖尿病患病率为20.4%,估计约为3538万,占总患病人数的38.1%。糖尿病是一组由多病因引起的以慢性高血糖为特征的代谢性疾病,是由胰岛素分泌和/或作用缺陷引起。遗传因素及环境因素共同参与其发病,其中肥胖、缺乏运动

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