糖基化终末产物抑制剂对糖尿病并发症的影响研究进展

发布时间：2018-02-02 14:01

本文关键词： 糖基化终末产物糖尿病并发症抑制剂　出处：《食品科技》2017年07期 　论文类型：期刊论文

【摘要】：蛋白质非酶糖基化是指蛋白质等大分子中的游离氨基,与还原糖经过一系列反应形成稳定的非酶糖基化终末产物(Advanced Glycation End products,AGEs)的过程。体内过多积累的AGEs改变蛋白质的理化性质和生理功能,诱导促炎介质的表达并引起氧化应激,引起细胞损伤,进而导致糖尿病及其并发症等一系列疾病的产生。阻断AGEs的形成有望成为改善糖尿病慢性并发症的新途径。天然产物AGEs抑制剂,作为改善糖尿病及糖尿病综合征的重要物质,近年来成为了备受关注的研究对象。文章旨在总结AGEs在糖尿病并发症中的重要作用,对目前已有的AGEs抑制剂和裂解剂的研究进展进行综述。重点论述天然AGEs抑制剂的研究进展,以期为寻找具有良好应用前景的天然药物和保健品提供线索。
[Abstract]:Non-enzymatic glycosylation of proteins refers to free amino groups in macromolecules such as proteins. After a series of reactions with reducing sugar, a stable end product of non-enzymatic glycosylation, Advanced Glycation End products, was formed. The excessive accumulation of AGEs in vivo changes the physicochemical properties and physiological functions of proteins, induces the expression of inflammatory mediators, and causes oxidative stress and cell damage. Thus leading to diabetes and its complications a series of diseases. Blocking the formation of AGEs is expected to be a new way to improve the chronic complications of diabetes. The natural product of AGEs inhibitor. As an important substance to improve diabetes mellitus and diabetic syndrome, AGEs has become the focus of research in recent years. This article aims to summarize the important role of AGEs in diabetic complications. The research progress of existing AGEs inhibitors and pyrolyzers is reviewed, with emphasis on the development of natural AGEs inhibitors. In order to find natural drugs and health products with good application prospects to provide clues.
【作者单位】：吉林农业大学食品科学与工程学院;韩国庆熙大学生命科学学院;吉林医药学院公共卫生学院;
【基金】：吉林省科技厅科技创新人才培育项目(20160519013JH);吉林省科技厅重大科技攻关项目(20160519013JH);吉林省科技厅青年科研基金项目(20150520133JH) 吉林省教育厅科学技术研究项目(吉教科合字[2016]第239号)
【分类号】：R587.2
【正文快照】： 蛋白质非酶糖基化是在非酶促的条件下,氨基酸、蛋白质或脂类等大分子的游离氨基与葡萄糖(Glucose)或果糖(Fructose)等还原糖,经缩合、重排、裂解、氧化修饰后产生的一系列稳定的非酶糖基化终末期产物(AGEs),也被称为美拉德反应产物或晚期糖基化终末产物。美拉德反应通常被用于

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