重庆市艾滋病抗病毒治疗效果及其影响因素分析

发布时间：2018-02-03 14:11

本文关键词： 艾滋病病人抗病毒治疗效果影响因素　出处：《中国艾滋病性病》2017年06期 　论文类型：期刊论文

【摘要】：目的了解重庆市艾滋病抗病毒治疗者的病毒载量(VL)抑制情况,分析其影响因素,为细化抗病毒治疗措施提供建议。方法采用回顾性研究方法,评估抗病毒治疗的病毒学效果。在国家艾滋病综合防治信息系统中下载抗病毒治疗病例的历史卡片,对数据库进行信息筛选和关联。数据核查后运用SPSS 18.0软件进行统计分析。结果 9 302例治疗患者平均年龄(44.6±14.7)岁,男性占75.3%,女性占24.7%。患者基线CD4~+T淋巴细胞(简称CD4细胞)平均值(中位数)为231个/μL,治疗后CD4细胞值平均为362个/μL。患者病毒载量检测结果400拷贝/mL的占89.5%,≥400拷贝/mL的占10.5%。多因素Logistic回归分析显示,同性性接触[比值比(OR)=1.60]、长期坚持治疗≥25个月(OR=1.46)、较高基线CD4细胞值、实施中默项目措施(OR=1.32),是患者治疗后VL有效抑制的保护性因素;静脉吸毒传播(OR=0.41)、治疗时间≤3月(OR=0.19)、最近7天漏服药物≥4次(OR=0.16)、最近出现过药品不良反应(OR=0.40),是患者治疗VL有效抑制的危险性因素。结论继续推行扩大治疗策略,针对影响治疗效果的影响因素细化工作措施,进一步提高治疗质量。
[Abstract]:Objective to understand the Chongqing City AIDS antiviral treatment in patients with viral load (VL) inhibition, analyze its influencing factors, to provide suggestions for treatment of refinement. Methods a retrospective study of antiviral effect evaluation method, virological antiviral treatment. Antiviral treatment case history card download in the comprehensive national AIDS prevention and control information system, information screening and related to the database. Data verification using SPSS 18 software for statistical analysis. Results 9302 patients average age (44.6 + 14.7) years old, accounted for 75.3% of men, women accounted for 24.7%. patients with baseline CD4~+T lymphocytes (CD4 cells) average (median) is 231 / L, the average value of CD4 cells after treatment 362 / L. viral load testing results with 400 copies of /mL accounted for 89.5%, more than 400 copies of /mL Logistic 10.5%. regression analysis showed that sex with [odds Than (OR) =1.60], long-term adherence to treatment more than 25 months (OR=1.46), higher baseline CD4 cell value, the default project implementation measures (OR=1.32), is a protective factor for patients with VL after treatment is suppressed; the spread of intravenous drug users (OR=0.41), the treatment time is March (OR=0.19), the last 7 days following medication more than 4 times (OR=0.16), recently appeared adverse drug reaction (OR=0.40), is a risk factor in patients with treatment of VL effectively suppressed. Conclusion to promote the expansion of treatment strategy, in view of the influence of the effect factors to refine the work measures to further improve the quality of treatment.

【作者单位】：重庆市公共卫生医疗救治中心;重庆市疾病预防控制中心;
【基金】：中国-默沙东艾滋病防治合作项目(A14004)~~
【分类号】：R512.91
【正文快照】： Supported by China-MSD HIV/AIDS PartnershipProject II(A14004)我国实施艾滋病“四免一关怀”政策以来,艾滋病抗病毒治疗(ART)挽救了大量艾滋病病人的生命,艾滋病病死率明显下降[1]。截至2015年11月,全国累计治疗成人病人458 417例,在治病人370 804例[2]。现有的艾滋病抗病

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