网络分析筛选六种与肥胖相关疾病的共同的肥胖基因（英文）

发布时间：2018-02-04 03:08

本文关键词： 肥胖肥胖相关疾病冠状动脉疾病高血压糖尿病乳腺癌肾癌多囊综合症　出处：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》2017年08期 　论文类型：期刊论文

【摘要】：目的:通过筛选在六种与肥胖相关疾病中发挥作用的共同的肥胖基因,阐明肥胖在疾病发生及发展中的作用,为预防及治疗肥胖相关的一系列疾病提供参考。创新点:首次分析了与肥胖相关疾病的共同的肥胖基因,为解释肥胖与疾病的关系提供理论支持。方法:从疾病及肥胖数据库中获得与疾病和肥胖相关的基因,利用生物信息学软件进行蛋白互作网络分析和中心基因分析,筛选中心基因;对疾病与肥胖数据库中的重叠基因进行GO(Gene Ontology,基因本体)功能富集,获得在疾病中发挥作用的共同的基因本体功能集群。结论:通过分析初步推测六种与肥胖相关疾病中的31个中心基因中包括17个肥胖基因,每种疾病与肥胖的重叠基因具有一些相同的基因本体功能集群。
[Abstract]:Objective: to elucidate the role of obesity in the pathogenesis and development of obesity by screening common obesity genes that play a role in the development of six obesity related diseases. For the prevention and treatment of a series of obesity related diseases. Innovation: the first analysis of obesity related diseases common obesity gene. To provide theoretical support for explaining the relationship between obesity and disease. Methods: the genes related to disease and obesity were obtained from the disease and obesity database. The protein interaction network analysis and central gene analysis were carried out by bioinformatics software. The overlapping genes in disease and obesity database were enriched with GO(Gene Ontology (gene ontology) function. Conclusion: through analysis, we preliminarily speculate that the 31 central genes of 6 kinds of obesity related diseases include 17 obesity genes. Overlapping genes of each disease and obesity have some of the same functional clusters of genes.
【作者单位】： Department
【基金】：supported by the Key Project of Hebei North University(No.120177) the Key Project of Medical Science Research in Hebei Province(No.20150061),China
【分类号】：R589.2
【正文快照】： http://dx.doi.org/10.1631/jzus.B1600454Obesity has been reported to be associated withmany diseases.However,common obesity-inducedbiological processes have not been evaluated acrossthese diseases.We identified genes associated withobesity and obesity-rel

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