中西医结合治疗原发性干燥综合征的Meta分析

发布时间：2018-02-04 13:16

本文关键词： Meta分析原发性干燥综合征随机对照　出处：《中华中医药学刊》2017年07期 　论文类型：期刊论文

【摘要】：目的:评价中西医结合治疗原发性干燥综合征的临床疗效。方法:计算机检索1979—2016年4月Pub Med、中文期刊网全文数据库(CNKI)、中国生物医学文献光盘数据库(CBM)、万方数据库以及中国优秀博硕士学位论文全文数据库(CDMD),对纳入文献依据Jadad量表进行质量评价和数据提取,并使用Rev Man 5.2版软件对纳入文献进行Meta分析。结果:共纳入10篇文献,共800例患者,其中治疗组420例,对照组380例,Jadad评分均为2分,所有纳入文献均未对随机分配方案进行隐藏,均未使用盲法。Meta分析结果显示:中西医结合治疗原发性干燥综合征在提高总有效率(OR 4.30,95%CI,[2.78,6.67])、ESR(MD-10.42,95%CI,[-12.57,-8.28]),CRP(MD-10.42,95%CI,[-9.44,-1.17]),血清Ig G(MD-3.52,95%CI,[-5.22,-1.82]),Schirmer试验(MD 4.63,95%CI,[-0.1,9.36]),唾液流率(MD 1.57,95%CI,[0.79,2.34])等方面均优于单纯的西医常规治疗,并且其差异具有统计学意义。结论:在西医常规治疗的基础上加用中医药的治疗,对原发性干燥综合征的总有效率、ESR、CRP、血清Ig G、Schirmer试验、唾液流率等方面均优于单纯的西医常规治疗,但本研究所纳入的Meta分析的文献质量普遍较低(Jadad评分3),而且存在发表性偏倚的可能,因此,更有待于设计规范严密的多中心、大样本、随机双盲对照试验进一步证实。
[Abstract]:Objective: to evaluate the clinical efficacy of integrated traditional Chinese and western medicine in the treatment of primary Sjogren's syndrome. Methods: Pub Med was searched by computer on April, 1979-2016. CNKI, China Biomedical document CD-ROM Database, Wanfang Database and China excellent Full-text Database of Master's degree and thesis (CDMDD). The quality evaluation and data extraction were carried out on the basis of Jadad scale, and Meta analysis was carried out with Rev Man 5.2 software. Results: 10 articles were included. A total of 800 patients, 420 cases in the treatment group, 380 cases in the control group Jadad score were 2 points, all included in the literature did not hide the random distribution scheme. The results of Meta-analysis showed that the total effective rate of the treatment of primary Sjogren's syndrome was improved by the combination of traditional Chinese and Western medicine. [2.786.67 [ESRN MD-10.42N95] CII, [-12.57 U -8.28] CRPU MD-10.42 / 95 CII, [-9.44ng-1.17, serum IGG MD-3.52 / 95 CII, [-5.22 + -1.82] / Schirmer test / MD 4.63 / 95 / CI. [-0.1% 9.36%, saliva flow rate, MD 1.57% and 95% CI, [The difference is statistically significant. Conclusion: on the basis of routine western medicine treatment, traditional Chinese medicine is added to the treatment. The total effective rate of primary Sjogren's syndrome (PSS) was better than that of routine western medicine alone, such as the total effective rate of ESR CRP, serum Ig GG Schirmer test, saliva flow rate and so on. However, the literature quality of Meta analysis included in this study is generally lower than that of Jadad score 3, and there is a possibility of publication bias. Therefore, it is necessary to design a strict multi-center and large sample. Randomized double-blind controlled trial further confirmed.
【作者单位】：浙江中医药大学;浙江中医药大学附属第二医院;
【基金】：国家重点基础研究发展计划(973计划)项目(2014CB543001) 浙江省教育厅一般科研项目(Y201431059) 浙江中医药大学校级科研基金人才专项项目(2013ZR02)
【分类号】：R593.2
【正文快照】： 原发性干燥综合征(primary Sjogren's syndrome,PSS),又被称之为原发性舍格林综合征,是一种主要累及外分泌腺体而造成的以口、眼干燥为主要临床表现的自身免疫性疾病。本病除累及外分泌腺外,常可出现腺体外症状,如关节炎、皮疹、肌痛以及内脏受累的症状。西医对于本病的治疗尚

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