2型糖尿病患者并发医院感染病原菌及血液学指标研究

发布时间：2018-02-05 02:54

本文关键词： 型糖尿病医院感染病原菌分布细胞因子　出处：《中华医院感染学杂志》2017年13期 　论文类型：期刊论文

【摘要】：目的分析2型糖尿病医院感染的病原菌分布及感染部位情况,探讨细胞因子在2型糖尿病患者发生医院感染时的变化。方法回顾性分析2015年1月-2016年9月在医院住院治疗2型糖尿病患者临床资料;依据患者是否发生医院感染将患者分为感染组(93例)及非感染组(98例),同时纳入同期健康体检者为对照组(60例);采用微生物全自动鉴定仪进行病原菌鉴定分型,比较各组细胞因子指标水平。结果 93例感染组患者共分离致病菌108株,其中革兰阴性菌53株占49.07%,革兰阳性菌44株占40.74%,真菌11株占10.19%;2型糖尿病医院感染的主要部位是肺部及上呼吸道占34.29%;感染组患者白细胞计数(WBC)(8.5±2.7×109/L)、C-反应蛋白(CRP)(23.7±6.9mg/L)、白介素-6(IL-6)(25.4±4.5ng/L)水平显著高于未感染组患者和对照组,差异有统计学意义(P0.05);感染组患者胰岛素样生长因子-1(IGF-1)(102.5±28.1ng/L)水平显著低于未感染组和对照组,差异有统计学意义(P0.05)。结论 2型糖尿病患者医院感染以革兰阴性菌为主,并且感染主要部位为肺部及上呼吸道,同时监测患者细胞因子的变化,有效控制2型糖尿病医院感染。
[Abstract]:Objective to analyze the distribution of pathogenic bacteria and the location of nosocomial infection in type 2 diabetes mellitus. Objective: to investigate the changes of cytokines in patients with type 2 diabetes mellitus during nosocomial infection. Methods Clinical data of patients with type 2 diabetes mellitus who were hospitalized from January 2015 to September 2016 were analyzed retrospectively. According to whether the patients had nosocomial infection, the patients were divided into infection group (n = 93) and non-infection group (n = 98). Results 108 strains of pathogenic bacteria were isolated from 93 patients with infection. Among them, 53 strains of Gram-negative bacteria accounted for 49.07%, 44 strains of Gram-positive bacteria accounted for 40.74 and 11 strains of fungi accounted for 10.19%. The main site of nosocomial infection in type 2 diabetes mellitus was the lung and upper respiratory tract. WBC count in infected group was 8.5 卤2.7 脳 10 ~ 9 / L CRP (23.7 卤6.9 mg / L). The level of IL-6 / L was significantly higher than that in the uninfected group and the control group (25.4 卤4.5 ng / L), and the difference was statistically significant (P 0.05). The level of insulin-like growth factor-1 IGF-1L in the infected group was significantly lower than that in the uninfected group and the control group (102.5 卤28.1 ng / L). Conclusion the nosocomial infection of type 2 diabetes patients is mainly Gram-negative bacteria, and the main site of infection is lung and upper respiratory tract, and the changes of cytokines are monitored. Effective control of type 2 diabetes nosocomial infection.
【作者单位】：邹城市人民医院医院感染管理办公室;
【基金】：山东省卫生厅基金资助项目(20150341)
【分类号】：R446.5;R587.2
【正文快照】： 2型糖尿病(T2DM)也称非胰岛素依赖型糖尿病,是一种全身性慢性疾病。患者由于体内糖、脂肪、蛋白质代谢功能紊乱,全身防御功能降低,免疫功能紊乱,对微生物入侵抵抗力下降,极易出现感染,且感染严重,很难控制,甚至威胁患者生命[1]。医院是使用各种医疗手段治疗疾病的场所,也是病

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