血清分泌型卷曲相关蛋白5与2型糖尿病及颈动脉粥样硬化的相关性研究

发布时间：2018-02-09 20:22

本文关键词： 糖尿病型血清分泌型卷曲相关蛋白颈动脉粥样硬化胰岛素抵抗　出处：《中国糖尿病杂志》2017年03期 　论文类型：期刊论文

【摘要】：目的探讨血清分泌型卷曲相关蛋白5(SFRP5)与T2DM及颈动脉粥样硬化(CAS)的相关性。方法根据颈动脉彩色多普勒超声结果,将56例T2DM患者分成T2DM合并CAS组(CAS组)28例和单纯CAS组(NAS组)28例,同时选取同期正常对照组(NGT组)28名。ELISA测定血清SFRP5浓度。结果 CAS组和NAS组血清SFRP5浓度较NGT组低[(114.36±25.48)vs(48.19±11.82),(43.88±8.19)pg/ml,P0.01];CAS组与NAS组血清SFRP5比较,差异无统计学意义。Pearson相关分析表明,血清SFRP5与年龄、TG、高敏C反应蛋白(hsC-RP)、FPG、FIns、HOMA-IR、HbA_1c、LDL-C、BMI呈负相关(r=-0.614,-0.160,-0.331,-0.682,-0.467,-0.580,-0.706,-0.339,-0.322,P0.01),与HDL-C呈正相关(r=0.386,P0.01),与性别、TC、SBP、DBP无相关性(P0.05)。多元线性逐步回归结果示,在排除混素因素后,年龄、FIns、HbA_1c是血清SFRP5的影响因素。结论 T2DM患者血清SFRP5浓度较正常人低,SFRP5可能是T2DM的保护因素,或可改善IR,该蛋白的合成可能有助于延缓或逆转T2DM的发生与进展,为T2DM患者的防治提供了新思路。
[Abstract]:Objective to investigate the relationship between serum secretory crimp associated protein 5SFRP5 and T2DM and carotid atherosclerosis. Methods according to the results of carotid color Doppler ultrasound, 56 patients with T2DM were divided into T2DM with CAS group (n = 28) and simple CAS group (n = 28). Results the serum SFRP5 concentration in CAS group and NAS group was lower than that in NGT group [114.36 卤25.48 卤11.82 卤48.19 卤11.82 vs 43.88 卤8.19 卤8.19 渭 g / ml P0.01] compared with NAS group, there was no significant difference in serum SFRP5 between CAS group and NAS group, Pearson correlation analysis showed that there was no significant difference in serum SFRP5 between CAS group and NAS group. Serum SFRP5 was negatively correlated with age, Gao Min C-reactive protein FInsInsHOMA-IRN HbA1cT, r-0.614- 0.160- 0.331mg-0.467- 0.580-0.706- 0.339- 0.3222P0.01a, and positively correlated with HDL-C, r0.386g / P0.01and no correlation with sex TCSBPDBP / P0.05. the results of multiple linear stepwise regression showed that, after removing the factors of mixed factors, there was no positive correlation between serum SFRP5 and HDL-C, and there was no correlation between LDL-CSBPDBP and TCSBPDBP. The results of multiple linear stepwise regression showed that, after removing the factors of mixed factors, there was no positive correlation between serum SFRP5 and HDL-C, and there was no correlation between LDL-CSBPDBP and TCSBPDBP, the results of multiple linear stepwise regression showed that, after removing the factors of mixed elements, there was no correlation between serum SFRP5 and HDL-C. Conclusion Serum SFRP5 concentration in patients with T2DM is lower than that in normal controls and may be a protective factor for T2DM, or can be improved. The synthesis of this protein may help to delay or reverse the occurrence and progression of T2DM. It provides a new idea for the prevention and treatment of T2DM patients.
【作者单位】：苏州大学附属第一人民医院内分泌科;
【基金】：上海市糖尿病重点实验室开放课题资助(SHKLD-KF-1403)
【分类号】：R587.1;R543.4

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