糖尿病患者幽门螺杆菌感染与颈动脉粥样硬化的相关性研究

发布时间：2018-02-10 05:29

  本文关键词： 糖尿病 动脉粥样硬化 幽门螺杆菌 感染　出处：《中华医院感染学杂志》2017年21期 　论文类型：期刊论文

【摘要】：目的研究糖尿病(DM)动脉粥样硬化患者临床前期幽门螺杆菌(HP)感染状况,分析患者幽门螺杆菌感染与颈动脉粥样硬化的相关性。方法选取2012年3月-2014年3月来医院进行治疗的DM患者160例,其中80例感染HP的患者设为试验组,未感染HP的患者设为对照组,比较两组患者的血糖、血脂、血压、颈动脉内膜中层厚度(IMT)以及炎性因子。结果试验组总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)均高于对照组,而高密度脂蛋白(HDL-C)较对照组而言有所减少,两组患者血脂比较差异有统计学意义(P0.05);试验组患者空腹血糖(FPG)低于对照组;而收缩压(SBP)、舒张压(DBP)均高于对照组,且两组患者的血压比较,差异有统计学意义(P0.05);试验组患者的IMT及炎性因子CRP、IL-6、IL-8均高于对照组患者,IL-10较对照组而言明显减少,两组患者的IMT及各炎性因子比较,差异有统计学意义(P0.05)。结论 DM患者较易感染HP,且HP的持续感染和患者颈动脉粥样硬化之间存在密切的关系,应予以重视,并进行针对性治疗。
[Abstract]:Objective to study the preclinical infection of Helicobacter pylori (HP) in patients with atherosclerotic diabetes mellitus (DMN). To analyze the correlation between Helicobacter pylori infection and carotid atherosclerosis. Methods A total of 160 DM patients who were treated in hospital from March 2012 to March 2014, 80 of whom were infected with HP, were selected as experimental group. The blood glucose, blood lipid, blood pressure, carotid intima-media thickness (IMT) and inflammatory factors were compared between the two groups. Results the levels of TC, TG, LDL-C in the experimental group were higher than those in the control group. However, HDL-C of high density lipoprotein (HDL-C) was lower than that of control group (P 0.05), fasting blood glucose (FPG) was lower in the trial group than that in the control group, but systolic blood pressure (SBP) and diastolic blood pressure (DBP) were higher than those in the control group. The difference of blood pressure between the two groups was statistically significant (P 0.05). The levels of IMT and IL-8 in the patients in the test group were significantly lower than those in the control group. The levels of IMT and inflammatory factors in the two groups were significantly lower than those in the control group. Conclusion DM patients are more susceptible to infection of HPand there is a close relationship between HP persistent infection and carotid atherosclerosis, which should be paid attention to and targeted treatment.
【作者单位】： 中国人民解放军第四十四医院内分泌科;
【基金】：贵州省卫生厅科学技术基金资助项目(20140753)
【分类号】：R587.2
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本文编号：1499765