视黄醇结合蛋白4与2型糖尿病糖脂代谢、胰岛素抵抗的相关研究

发布时间：2018-02-10 22:44

本文关键词： 2型糖尿病视黄醇结合蛋白4 胰岛素抵抗指数　出处：《广西医科大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的探讨血清视黄醇结合蛋白4(RBP4)与2型糖尿病糖脂代谢、胰岛素抵抗的关系方法1、研究对象:2型糖尿病组:选在我院住院的73例无并发症的2型糖尿病(T2DM)患者,男41例,女32例;对照组:来我院同期体检的31例健康人群,男11例,女20例。2、收集两组的性别、年龄、身高、体重等一般临床资料,清晨空腹抽取空腹血糖(FPG)、空腹胰岛素(FINS)、糖化血红蛋白(HbA1c)、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白-胆固醇(HDL-C)、低密度脂蛋白-胆固醇(LDL-C)、肝肾功能等。计算胰岛素分泌指数(HOMA-β)=FINS(mmol/L)×20/(FPG(mmol/L)-3.5)、胰岛素抵抗指数(HOMA-IR)=FPG(mmol/L)×FINS(mmol/L)/22.5、体重指数(BMI)=体重(Kg)/身高(m)2;3、比较两组资料FPG、FINS、HOMA-β、HOMA-IR、HbA1c、TG、TC、HDL-C、LDL-C、RBP4的差异;4、利用spearman相关分析,比较RBP4与FPG、FINS、HOMA-β、HOMA-IR、HbA1c、TG、TC、HDL-C、LDL-C、BMI的相关性;5、用多元逐步回归分析探讨影响2型糖尿病患者血清RBP4的因素。结果1、T2DM组的FPG、FINS、HbA1c、TG、TC高于对照组,HDL-C低于对照组,p0.05;2、T2DM组的HOMA-IR高于对照组,p0.05,HOMA-β低于对照组,p0.05;3、两组的RBP4比较示T2DM组的RBP4高于对照组,p0.05;4、采用spearman相关分析结果显示,RBP4与FPG、HbA1c、TG呈正相关,r值分别为0.320,0.284,0.334,P0.05。5、以RBP4为因变量,FPG、HbA1c、TG为自变量,采用多元逐步回归分析结果示TG是血清RBP4的影响因素。结论1、T2DM组的血清RBP4高于对照组;2、血清RBP4可能参与T2DM的糖脂代谢紊乱过程;3、TG可能是RBP4的影响因素。
[Abstract]:Objective to investigate the relationship between serum retinol binding protein 4 (RBP4) and glucose and lipid metabolism and insulin resistance in type 2 diabetes mellitus. Objective to investigate the relationship between serum retinol binding protein 4 (RBP4) and glucose and lipid metabolism and insulin resistance in type 2 diabetes mellitus. Objective to investigate the relationship between serum retinol binding protein 4RBP4 and glucose and lipid metabolism and insulin resistance in type 2 diabetes mellitus. There were 32 women and 31 healthy people (11 males and 20 females) in the control group. The general clinical data of sex, age, height, weight and so on were collected from the two groups, such as sex, age, height, weight and so on. Fasting fasting blood glucose (FPG), fasting insulin (FIN), glycosylated hemoglobin (HbA1cN), triglyceride (TGN), total cholesterol (TC), high density lipoprotein (HDL-C), low density lipoprotein (LDL) -cholesterol (LDL-C), liver and kidney function were extracted in the morning. The difference of insulin resistance index (HOMA-IRR) 脳 FINSINSmol-L / L 脳 FINSMO-L / L) 脳 HOMA-IRFPGmol-L% 22.5, body mass index (BMI) = body mass index (spearman) = body mass index (spearman) = body mass index (KG) / height (MK) was compared between the two groups, and the difference between the two groups was compared between the two groups, and the difference of HDL-CLDL-CnRBP4 between the two groups was analyzed by spearman correlation analysis. To compare the correlation between RBP4 and HOMA- 尾 HbA1 HbA1cTGG (HbA1 cTGN) TGG, and to explore the factors influencing the serum RBP4 of type 2 diabetes mellitus patients by multivariate stepwise regression analysis. Results 1 the HOMA-IR of RBP4 in T2DM group was higher than that in control group (P < 0.05), and the HOMA-IR in TGG group was higher than that in control group (P < 0.05), and the level of HOMA-IR in TGG group was higher than that in control group (p 0.05HOMA- 尾 was lower than that in control group p0.05HOMA- 尾 was lower than that in control group p0.05HOMA- 尾 lower than that in control group p0.05HOMA- 尾). The RBP4 of T2DM group was higher than that of control group (P 0.05). The results of spearman correlation analysis showed that there was a positive correlation between RBP4 and HbA1cU TG in T2DM group, and the positive correlation between RBP4 and HbA1cFG in T2DM group was 0.320 / 0.284 / 0.334P0.05.5, respectively. RBP4 as a dependent variable, HbA1ctroglycerin was an independent variable, and the results of spearman correlation analysis showed that there was a positive correlation between RBP4 and HbA1cTr in T2DM group. The results of multiple stepwise regression analysis showed that TG was the influencing factor of serum RBP4. Conclusion 1 the serum RBP4 of T2DM group is higher than that of control group, and serum RBP4 may be involved in the disorder of glucose and lipid metabolism of T2DM. TG may be the influencing factor of RBP4.
【学位授予单位】：广西医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R587.1

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