新诊2型糖尿病患者血浆视黄醇结合蛋白4与亚临床动脉粥样硬化的关系

发布时间：2018-02-15 02:59

本文关键词： 视黄醇结合蛋白新诊型糖尿病亚临床动脉粥样硬化　出处：《中国动脉硬化杂志》2016年04期 　论文类型：期刊论文

【摘要】：目的探讨新诊2型糖尿病(T2DM)患者血浆视黄醇结合蛋白4(RBP4)与亚临床动脉粥样硬化(subAs)的关系。方法对217例新诊T2DM患者测定血浆RBP4浓度、空腹及餐后血糖、糖化血红蛋白、血脂、空腹胰岛素及颈总动脉内膜中膜厚度(IMT)、髂总动脉IMT、股动脉IMT,分析其subAs的发生情况。结果合并subAs的T2DM患者平均年龄、空腹胰岛素、血浆RBP4浓度均高于非subAs组患者(均P0.05)。将患者按RBP4浓度三分位数分组,随RBP4浓度增加,患者颈总动脉IMT、髂总动脉IMT、股动脉IMT均增加,高浓度RBP4组患者的颈总动脉IMT高于其余两组(P0.05);随RBP4浓度增加,subAs患病率也逐步升高,高浓度RBP4组患者的subAs患病率显著高于其余两组(P0.05)。相关分析显示新诊T2DM患者RBP4浓度与颈总动脉IMT、髂总动脉IMT、体质指数、收缩压、血糖、空腹胰岛素呈正相关。多元逐步Logistic回归分析显示:新诊T2DM患者subAs的发生与血浆RBP4、年龄、低密度脂蛋白胆固醇显著相关。结论新诊T2DM患者血浆RBP4水平与subAs呈正相关关系,血浆RBP4升高可能是新诊T2DM患者subAs的独立危险因素之一。
[Abstract]:Objective to investigate the newly diagnosed type 2 diabetes mellitus (T2DM) patients with plasma retinol binding protein 4 (RBP4) and subclinical atherosclerosis (subAs) relationship. Methods 217 cases of newly diagnosed T2DM patients plasma RBP4 concentrations were measured in fasting and postprandial blood glucose, glycosylated hemoglobin, blood lipid, fasting insulin and intima of carotid artery in film the thickness (IMT), common iliac artery and femoral artery IMT, IMT, subAs. The analysis of the average age of T2DM patients results with subAs fasting insulin, plasma concentrations of RBP4 were higher than those in non subAs group (P0.05). The patients in the concentration of RBP4 in the three quartile groups increased with the concentration of RBP4 patients the IMT of carotid artery, common iliac artery and femoral artery were increased IMT, IMT, IMT of carotid artery in RBP4 group were high concentration higher than the other two groups (P0.05); with the increase of RBP4 concentration, the prevalence rate of subAs gradually increased, the high concentration of subAs in RBP4 group were significantly higher than that of the other two prevalence rate Group (P0.05). Correlation analysis showed that the concentration of RBP4 in T2DM patients with carotid artery IMT, iliac artery IMT, body mass index, systolic blood pressure, blood glucose, fasting insulin was positively correlated. Stepwise Logistic regression analysis showed that: the plasma RBP4 and T2DM patients, subAs was significantly related to age, low density lipoprotein cholesterol. Conclusion T2DM patients plasma RBP4 level is positively correlated with subAs, the increased plasma RBP4 may be one of the independent risk factors of newly diagnosed T2DM patients with subAs.

【作者单位】：南华大学医学院;中南大学湘雅二医院糖尿病中心;
【基金】：湖南省自然科学基金(2013FJ4236) 教育部博士点基金(20110162120014) 湖南省教育厅优秀青年项目(13B098)
【分类号】：R587.1

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