老年百草枯中毒患者血清酶学水平的动态变化

发布时间：2018-02-20 03:31

本文关键词： 百草枯肌酸激酶肌酸激酶同工酶乳酸脱氢酶碱性磷酸酶　出处：《中国老年学杂志》2016年16期 　论文类型：期刊论文

【摘要】：目的探讨老年百草枯中毒患者血清酶学水平的动态变化。方法选取56例老年百草枯中毒患者作为研究组,同期体检的健康人群70例作为健康对照组。检测老年百草枯中毒患者血清肌酸激酶(CK)、CK同工酶(CK-MB)、乳酸脱氢酶(LDH)、碱性磷酸酶(AST)等指标。结果与健康对照组比较,中毒第1天轻度组血清CK、CK-MB、LDH、AST水平差异无统计学意义(P0.05);但中度组和重度组患者血清CK、CK-MB、LDH、AST水平均高于健康对照组(P0.05);且三组间两两比较均有统计学差异(P0.05)。轻度组血清CK、CK-MB、LDH、AST水平在第3天达峰值,但在第7天开始下降。中度组和重度组血清CK、CK-MB、LDH、AST水平不断升高,在第7天达到峰值。第3、7天时,三组间血清CK、CK-MB、LDH、AST水平两两比较均有统计学差异(P0.05)。结论百草枯中毒可造成老年患者心肌损害持续性加重,且心肌损害程度与百草枯中毒程度相关。
[Abstract]:Objective to investigate the dynamic changes of serum enzyme level in senile paraquat poisoning patients. Methods 56 senile paraquat poisoning patients were selected as the study group. The serum creatine kinase (CK) and CK isoenzyme (CK-MBN), lactate dehydrogenase (LDH) and alkaline phosphatase (AST) were measured in 70 healthy people as control group. Results the results were compared with those in the healthy control group. On the first day of poisoning, there was no significant difference in the level of serum CKCK-MBP LDHNAST between mild group and severe group (P 0.05), but the level of CKCK-MBN LDHNAST in moderate group and severe group was higher than that in healthy control group (P 0.05), and there was a statistical difference among the three groups (P 0.05). The serum level of CKCK-MBP LDHNAST in mild group was significantly higher than that in control group (P 0.05). Peaked on the third day, But it began to decrease on the 7th day. The level of serum CKK-MBN LDHNAST in the moderate and severe groups increased continuously, and reached its peak on the 7th day, and reached its peak on the 3th day. There were significant differences in serum CKK-MBN LDHN AST levels among the three groups. Conclusion Paraquat poisoning can cause persistent myocardial damage in elderly patients, and the degree of myocardial damage is related to the degree of paraquat poisoning.
【作者单位】：遵义医学院附属医院急诊科;
【基金】：国家自然科学基金(No.81460291) 遵义医学院基金项目[院字(2014)32号]
【分类号】：R595.4

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