IL-2、IL-6和TGF-β在老年甲状腺肿并甲亢患者体内表达水平及其临床意义

发布时间：2018-02-20 22:54

本文关键词： 甲状腺肿大甲状腺功能亢进症白细胞介素- 白细胞介素- 转化生长因子β　出处：《中国地方病防治杂志》2016年04期 　论文类型：期刊论文

【摘要】：目的探讨IL-2、IL-6和TGF-β在老年甲状腺肿并甲状腺功能亢进症(甲亢)患者体内表达水平及其临床意义。方法 128例以甲状腺肿并甲亢就诊于宁夏医科大学附属医院内分泌科的老年患者作为病例组;另外选择128例甲状腺肿大未合并甲亢的60岁以上老年人作为对照组。使用细针穿刺活检方法,对两组患者的甲状腺组织进行病理学检查,使用免疫组化、QT-PCR及Western Blot的方法分别检测两组患者甲状腺组织IL-2、IL-6、TGF-β的表达情况。结果与对照组相比,病例组患者IL-2、IL-6、TGF-β的表达明显增高,差异具有统计学意义(P0.05),IL-2、IL-6、TGF-β高表达主要集中在甲亢和甲状腺肿大患者的甲状腺滤泡细胞中,与对照组相比,表达量的差异具有统计学意义(P0.05)。在有突眼症状的甲状腺肿合并甲亢患者中,IL-6的表达比无突眼患者高,差异具有统计学意义(P0.05);但在突眼和无突眼的甲亢和甲状腺肿大患者中,IL-2和TGF-β表达水平差异无统计学意义(P0.05)。结论在老年性甲状腺肿合并甲亢患者中,患者病变组织中IL-2、IL-6及TGF-β表达水平明显增高。但在具有突眼症状的老年性甲状腺肿合并甲亢患者中,IL-6水平明显高于无突眼者。使用IL-2、IL-6及TGF-β等对于诊断甲状腺肿大合并甲亢具有重要意义,尤其对于老年的甲亢临床症状不典型患者,具有重要的提示作用。
[Abstract]:Objective to investigate the expression of interleukin-6 (IL-6) and TGF- 尾 in elderly patients with goiter and hyperthyroidism (hyperthyroidism) and their clinical significance. Methods 128 patients with goiter and hyperthyroidism were treated in the affiliated Hospital of Ningxia Medical University. The elderly patients in the department of secretion were treated as the case group. In addition, 128 patients over 60 years old with goiter and hyperthyroidism were selected as control group. The thyroid tissues of the two groups were examined by fine needle biopsy. The expression of IL-2TGF- 尾 in thyroid tissue was detected by immunohistochemistry and Western Blot. Results compared with the control group, the expression of IL-2TGF- 尾 in the thyroid tissue of the patients was significantly higher than that in the control group, and the expression of IL-2TGF- 尾 in the thyroid tissue of the two groups was significantly higher than that in the control group. The high expression of IL-2TGF- 尾 in thyroid follicular cells of patients with hyperthyroidism and goiter was significantly higher than that in control group. The expression of IL-6 was significantly higher in patients with exophthalmic goiter complicated with hyperthyroidism than in patients with anophthalmos. The difference was statistically significant (P 0.05), but there was no significant difference in the expression of IL-2 and TGF- 尾 in patients with hyperthyroidism and goiter. Conclusion in the elderly patients with goiter and hyperthyroidism, there is no significant difference in the expression of IL-2 and TGF- 尾. Conclusion there is no significant difference in the expression of IL-2 and TGF- 尾 in patients with hyperthyroidism. The expression levels of IL-6 and TGF- 尾 were significantly higher in patients with exophthalmic goiter than in patients with hyperthyroidism. The expression of IL-6 and TGF- 尾 were significantly higher in patients with goiter with exophthalmos than in patients with hyperthyroidism. The use of IL-6 and TGF- 尾 in the diagnosis of goiter was helpful in the diagnosis of goiter. Hyperthyroidism is of great significance. Especially for the elderly hyperthyroidism clinical symptoms atypical patients, has an important role in prompting.
【作者单位】：宁夏医科大学基础医学院;延安市人民医院检验科;河南中医药大学教学实验中心;宁夏医科大学附属总医院外科;
【基金】：宁夏自然科学基金;基金号:NZ14087
【分类号】：R581

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