丽水市HIV-1抗体阳性人群WB带型分析

发布时间：2018-02-23 16:40

本文关键词： 艾滋病病毒抗体蛋白印迹试验带型分析　出处：《中国艾滋病性病》2017年03期 　论文类型：期刊论文

【摘要】：目的了解丽水市艾滋病病毒-1(HIV-1)阳性人群蛋白印迹试验(WB)的带型分布特征,为制定该市艾滋病防控措施提供科学依据。方法对于HIV确证阳性样本采用WB检测,结果严格按照试剂盒说明书判断,并用SPSS 16.0统计软件分析。结果 697例HIV-1确证阳性标本中,除p55和p17抗体出现率分别为42.49%(296例)和75.61%(527例)较低外,其余带型出现率均在92%以上;带型组合以全带和次全带为主(85.51%,596例)。不同性别中p17抗体出现率差异有统计学意义(χ~2=4.927,P=0.026);不同年龄组中p24抗体出现率差异有统计学意义(χ~2=7.998,P=0.046);不同性传播途径中p51和p17抗体出现率差异均有统计学意义(χ~2=8.384,P=0.004)和(χ~2=11.826,P=0.001);不同人群中p17抗体出现率差异有统计学意义(χ~2=13.71,P=0.033)。结论不同性别、人群和传播途径中,p17或p51抗体检出率存在显著性差异;p24抗体在60岁以上老年组丢失显著增多,说明该人群处于艾滋病期较多,应加强该人群监测力度。丽水市处于HIV感染增长快速期,对WB带型特征在不同人群中的分析,为该地区HIV疫情防控提供科学依据。
[Abstract]:Objective to investigate the distribution characteristics of HIV positive population in Lishui city, and to provide scientific basis for the development of AIDS prevention and control measures in Lishui City. Methods WB was used to detect the positive HIV positive samples in Lishui city. Results according to the specification of the kit, the results were analyzed by SPSS 16.0 statistical software. Results in the 697 HIV-1 confirmed positive specimens, the prevalence rates of p55 and p17 antibodies were 42.49296,75.61and 527 respectively), and the other band types were all above 92%. There were significant differences in the prevalence of p17 antibody among different genders (蠂 2 / 2 / 4.927 / P 0.026) and in different age groups (蠂 ~ 2 / 7.998p 0.04646; p 51 and p17 antibody in different ways of transmission). There were statistically significant differences in the incidence of p17 antibody between different population groups (蠂 ~ (2 / 2) 8.384 / P ~ (0.004)) and (蠂 ~ (2 +) = 11.826 / P ~ (0.001) P ~ (0.001)), and there was a significant difference in the incidence of p17 antibody among different population groups (蠂 ~ (2 +) ~ (13.71) P ~ (0.033) P ~ (0.033)). There was a significant difference in the detection rate of p17 or p51 antibody between the population and the transmission route. The loss of p24 antibody in the elderly group over 60 years old was significantly increased, which indicated that the population was in the AIDS stage. The surveillance of this population should be strengthened. Lishui City is in the period of rapid growth of HIV infection. The analysis of WB band pattern in different populations provides scientific basis for the prevention and control of HIV epidemic situation in this area.
【作者单位】：丽水市疾病预防控制中心;
【基金】：浙江省医药卫生科技计划项目(2014KYB318) 丽水市科技计划项目(2014RC19)~~
【分类号】：R512.91

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