不同剂量α-硫辛酸对2型糖尿病患者尿足细胞标志蛋白及血管内皮生长因子的影响

发布时间：2018-02-24 12:20

本文关键词： 型糖尿病 α-硫辛酸尿足细胞标志蛋白血管内皮生长因子　出处：《中国医院药学杂志》2016年09期 　论文类型：期刊论文

【摘要】：目的:探讨不同剂量α-硫辛酸(ALA)对2型糖尿病(T2DM)患者尿足细胞标志蛋白(PCX)、血管内皮生长因子(VEGF)及尿白蛋白(UALB)的影响。方法:92例T2DM患者分为常规治疗组(DM组32例)、ALA治疗组[DM 300mg(30例)及DM 600mg(30例),分别给予ALA 300mg及ALA 600mg静脉滴注,每日一次)。另选34例正常对照者(NC组)。分别于0周及2周测定尿PCX、血VEGF、尿肌酐(Ucr)及UALB。结果:DM 300mg组及DM 600mg组治疗2周后VEGF、尿PCX肌酐比(UPCR)、尿白蛋白肌酐比(UACR)低于DM组(P0.05或P0.01),DM 600mg组VEGF、UPCR、UACR低于DM 300mg组(P均0.05)。结论:ALA可通过抗氧化应激减少尿PCX的排泄,降低血VEGF,减轻足细胞的损伤和凋亡,并呈一定的剂量依赖性。
[Abstract]:Objective: to investigate the effects of different doses of 伪 -lipoic acid (伪 -lipoic acid) on urinary podocyte marker protein (PCX), vascular endothelial growth factor (VEGF) and urinary albumin (UALB) in patients with type 2 diabetes mellitus (T2DM). Methods: 92 cases of T2DM patients with T2DM were divided into control group (n = 32) and control group (n = 32). In the treatment group (DM 300mg / g 30 cases) and DM 600mg / L (30 cases), ALA 300mg and ALA 600mg were given intravenously, respectively. Urine PCX, blood VEGF, urinary creatinine (UCR) and UALB were measured at 0 and 2 weeks after treatment. Results after 2 weeks of treatment, the levels of PCX creatinine, urinary albumin creatinine and urinary albumin creatinine in the 300mg and 600mg groups were lower than those in the DM group. Conclusion the excretion of PCX in urine can be reduced by anti-oxidation stress, and the UACR of VEGF UPC UACR in DM 600mg group is lower than that in DM 300mg group (P 0.05 or P 0.01). The level of VEGF was decreased and the damage and apoptosis of podocyte were alleviated in a dose-dependent manner.
【作者单位】：河北医科大学第一医院内分泌科;河北医科大学第一医院检验科;
【基金】：河北省卫生厅重点科技研究计划(编号:20130260)
【分类号】：R587.1

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