风湿活动度预测绝经后女性类风湿关节炎患者骨密度的研究

发布时间：2018-02-25 19:01

本文关键词： 绝经后类风湿关节炎骨密度 DAS 年龄　出处：《中国骨质疏松杂志》2016年05期 　论文类型：期刊论文

【摘要】：目的探讨能够预测绝经后女性类风湿关节炎(Rheumatoid Arthritis RA)患者骨质疏松的指标。方法收集100例绝经后女性RA患者一般临床资料包括年龄、病程、血沉、C反应蛋白、类风湿因子、抗环瓜氨酸肽抗体、关节疼痛数目、关节肿胀数目,采用双能量X线骨密度仪测量腰椎、股骨及全身总的平均骨密度,比较临床资料并分析可能影响骨密度的因素。结果1.绝经后女性类风湿关节炎患者骨质疏松比例为33%,骨量减少比例47%,骨量正常比例20%。2.骨质疏松组的年龄、病程、血沉、关节疼痛数目、DAS28均高于非骨质疏松组,且有统计学意义。3.采用Logistic回归分析结果显示,年龄和DAS28是绝经后女性RA患者骨密度的独立危险因素。4.骨密度T值为诊断骨质疏松的金标准绘制受试者工作曲线,计算DAS28、年龄诊断骨质疏松的切点为5.3分和59.5岁。结论风湿活动度和年龄对于绝经后女性RA患者有较强的骨质疏松预警作用。
[Abstract]:Objective to explore the indexes of predicting osteoporosis in postmenopausal women with rheumatoid Arthritis RA.Methods General clinical data of 100 postmenopausal women with RA including age, course of disease, erythrocyte sedimentation rate C reactive protein, rheumatoid factor were collected. The total mean bone mineral density (BMD) of lumbar vertebrae, femur and whole body was measured by dual energy X-ray absorptiometry, including anti-cyclic citrullin-peptide antibody, number of joint pain and joint swelling. Comparison of clinical data and analysis of possible factors affecting bone mineral density. Results 1. The proportion of osteoporosis in postmenopausal women with rheumatoid arthritis was 33, the ratio of bone mass reduction was 47, and the ratio of normal bone mass was 20.2. the age, course of disease, erythrocyte sedimentation rate of osteoporosis group, The number of joint pain in DAS28 group was higher than that in non-osteoporosis group, and there was statistical significance. 3. The results of Logistic regression analysis showed that, Age and DAS28 were independent risk factors for bone mineral density in postmenopausal women with RA. T value of bone mineral density was the gold standard for the diagnosis of osteoporosis. DAS28 was calculated, and the cutting point for diagnosis of osteoporosis was 5.3 and 59.5 years old. Conclusion Rheumatic activity and age have a strong early warning effect on postmenopausal women with RA.
【作者单位】：江苏省苏北人民医院风湿免疫科;
【分类号】：R593.22

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