血清羧化不全骨钙素对绝经后女性骨质疏松症诊疗意义的探讨

发布时间：2018-02-26 14:52

本文关键词： 羧化不全骨钙素骨质疏松症绝经后女性骨密度　出处：《中国骨质疏松杂志》2017年12期 　论文类型：期刊论文

【摘要】：目的检测绝经后女性血清羧化不全骨钙素(ucOC)的水平,并探讨其影响因素及其对绝经后女性骨质疏松症诊疗的意义。方法选择南京医科大学附属南京医院2015年07月至2016年12月在骨科门诊就诊的绝经后女性患者108例,依据骨密度检查将这些患者分为骨质疏松组与非骨质疏松组;记录其年龄、身高、体重、体重指数(BMI)、绝经年龄、骨密度(BMD)等相关资料;抽取外周血测定碱性磷酸酶(ALP)、血钙、血磷、羧化不全骨钙素(ucOC)的水平,并对上述资料进行相关的统计学分析。结果绝经后女性骨质疏松组患者的血清ucOC水平与非骨质疏松组相比差异有统计学意义(P0.05);血清ucOC水平是骨质疏松症的影响因素(OR=2.806,P0.05)。(2)血清ucOC水平与腰椎骨密度呈负相关(r=-0.395,P0.05),但与髋关节骨密度无显著相关性(r=-0.248,P0.05)。结论血清ucOC水平的变化与绝经后女性骨质疏松症的发生关系密切,血清高ucOC水平是绝经后女性骨质疏松症发生的危险因素;推断血清ucOC水平对于绝经后女性骨质疏松症早期的预测和筛查具有参考意义
[Abstract]:Objective to detect the serum carboxylation of osteocalcin (BOC) in postmenopausal women. Methods 108 postmenopausal female patients in Nanjing Hospital affiliated to Nanjing Medical University from July 2015 to December 2016 were selected. These patients were divided into osteoporosis group and non-osteoporosis group according to bone mineral density examination, and recorded their age, height, weight, body mass index (BMIA), menopausal age, bone mineral density (BMD), etc. Blood phosphorus, carboxylation incomplete osteocalcin (BOC) levels, Results the serum ucOC level in postmenopausal women with osteoporosis was significantly higher than that in non-osteoporosis group (P 0.05), and the serum ucOC level was the cause of osteoporosis. Serum ucOC level was negatively correlated with lumbar vertebrae bone mineral density, but had no significant correlation with hip bone mineral density. Conclusion the change of serum ucOC level is closely related to postmenopausal women with osteoporosis. High serum ucOC level is a risk factor for postmenopausal women with osteoporosis, and the conclusion of serum ucOC level has reference significance for early prediction and screening of postmenopausal women with osteoporosis.
【作者单位】：南京医科大学附属南京医院;
【基金】：中国博士后科学基金面上项目(2012M511301)
【分类号】：R580

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