多囊卵巢综合征患者妊娠母血及脐血中胰岛素样生长因子-1水平对妊娠结局的影响

发布时间：2018-02-27 01:36

本文关键词： 多囊卵巢综合征妊娠结局胰岛素样生长因子-　出处：《实用医学杂志》2016年01期 　论文类型：期刊论文

【摘要】：目的:检测多囊卵巢综合征(PCOS)患者妊娠母血及脐血中胰岛素样生长因子-1(IGF-1)水平,判定IGF-1与PCOS患者妊娠结局的关系,探讨IGF-1是否可作为PCOS妊娠患者诊断标记物。方法:收集2012年1月至2013年12月本院120例PCOS患者妊娠母血及脐血作为PCOS组,同期收集无PCOS史120例的正常孕产妇妊娠母血及脐血作为对照组,ELISA法检测IGF-1水平,并对两组患者不同妊娠结局进行分析。结果:PCOS组妊娠母血及脐血中IGF-1的水平均显著上升,与对照组相比,差异有统计学意义(P0.05)。PCOS组患者妊娠结局死胎、早产、巨大儿发生率均显著高于对照组(P0.05):PCOS组所有妊娠结局不良患者妊娠母血及脐血中IGF-1均显著高于对照组(P0.05)。结论:IGF-1可作为PCOS患者妊娠结局风险预测标记物。
[Abstract]:Objective: to detect the polycystic ovary syndrome (PCOS) and insulin-like growth factor -1 in patients with pregnancy in maternal and umbilical cord blood (IGF-1) level, to determine the relationship between IGF-1 and pregnancy outcomes in patients with PCOS, to investigate whether IGF-1 can be used as a diagnostic marker of pregnancy in patients with PCOS. Methods: from January 2012 to December 2013 in our hospital 120 cases of PCOS patients with pregnancy in maternal blood as the PCOS group and umbilical cord blood collected during the same period, 120 cases of normal pregnant women without PCOS history of pregnancy, maternal and umbilical cord blood as control group, to detect the level of IGF-1 ELISA, and the two groups of patients with different pregnancy outcomes were analyzed. Results: IGF-1 PCOS group of pregnancy in maternal and umbilical cord blood levels were significantly increased compared with the control group, the difference was statistically significant (P0.05) in.PCOS group the pregnancy outcome in patients with stillbirth, premature birth, macrosomia rate were significantly higher than control group (P0.05): PCOS group all adverse pregnancy outcome in patients with pregnancy in maternal and umbilical cord blood IGF-1 were significantly It was higher than the control group (P0.05). Conclusion: IGF-1 can be used as a marker for predicting the risk of pregnancy outcome in patients with PCOS.

【作者单位】：三峡大学第一临床医学院&宜昌市中心人民医院;
【基金】：湖北省自然科学基金项目(编号:2014CFB307)
【分类号】：R711.75

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