高效抗逆转录病毒疗法治疗艾滋病患者的疗效与安全性

发布时间：2018-02-27 10:54

  本文关键词： 高效抗逆转录病毒疗法 艾滋病 CD~+T淋巴细胞计数 病毒载量　出处：《中国临床药理学杂志》2017年17期 　论文类型：期刊论文

【摘要】：目的研究高效抗逆转录病毒疗法(HAART)在艾滋病(HIV)患者中的应用。方法入选2013年6月至2015年1月本院收治的艾滋病患者60例为研究对象,对所有患者均给予高效抗逆转录病毒疗法,采取联合治疗:拉米夫定0.3 g qd,齐多夫定0.3 g bid,依非韦伦600 mg qn。治疗后3,6,12个月,比较患者的CD4~+T淋巴细胞计数和HIV病毒载量变化,分析患者的临床疗效和药物不良反应。结果治疗12个月后患者的有效率为93.33%(56/60例)。CD4~+T淋巴细胞计数和病毒载量:与治疗前的(104.74±9.58)pcs·μL~(-1)、(7.76±0.42)g·copies·m L~(-1)比较,治疗3个月后分别为(144.64±6.47)pcs·μL~(-1)、(4.80±0.20)g·copies·m L~(-1),差异均有统计学意义(均P0.05)。有7例患者发生骨髓抑制,5例发生肝毒性(在治疗后1,2个月出现),3例出现Ⅱ级末梢神经炎(在治疗后3,4,6个月出现)。结论 HAART疗法对HIV患者进行治疗,免疫学和病毒学效果良好。
[Abstract]:Objective to study the application of HAART in HIV / AIDS patients. Methods 60 AIDS patients admitted from June 2013 to January 2015 were included in the study, and all patients were treated with high effective antiretroviral therapy. Combined treatment: lamivudine 0.3 g QD, zidovudine 0.3 g bid, efeverun 600 mg Qn.Three months and 12 months after treatment, the changes of CD4T lymphocyte count and HIV viral load were compared. Results after 12 months of treatment, the effective rate of the patients was 93.33 / 56 / 56 / 60 / 56 / 60 / 60 / 60 / 60 / 60 / 60 / 60 / 60 / 60 / 60 / 60 / 60 / 60 / 60 / 60 / 60 / 60 / 60 / 60 / 60 / 60 / 60 / 60 / 60 / 60 / 60 cases: compared with the pre-treatment period of 104.74 卤9.58pcs 路渭 L ~ (-1) and 7.76 卤0.42 g / copies 路mL ~ (-1), respectively, the clinical efficacy and adverse drug reactions of the patients were analyzed. After 3 months of treatment, it was 144.64 卤6.47g 路渭 L copies 路copies 路copies 路L ~ (-1) (4.80 卤0.20g 路copies 路mL ~ (-1)), respectively. The difference was statistically significant (all P 0.05). There were 7 cases of bone marrow suppression and 5 cases of hepatotoxicity (1 month, 2 months after treatment) and 3 cases of grade 鈪，

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