2型糖尿病患者促甲状腺激素与同型半胱氨酸的关系

发布时间：2018-02-28 22:16

  本文关键词： 2型糖尿病 促甲状腺激素 同型半胱氨酸　出处：《宁夏医科大学》2015年硕士论文　论文类型：学位论文

【摘要】：目的探讨2型糖尿病(T2DM)患者血清中促甲状腺激素(TSH)与同型半胱氨酸(HCY)的关系。方法收集2012年12月--2014年4月宁夏医科大学第二附属医院内分泌科住院的T2DM患者200例为糖尿病组,年龄(55±15)岁,病程(5.4±3.7)年,其中男性患者88例,女性患者112例。将200例未合并甲状腺疾病的2型糖尿病患者按促甲状腺激素(TSH)水平分组:TSH0.3(UIu/m L)组33例,0.3≤TSH≤5.5组132例,TSH5.5组35例;收集宁夏医科大学第二附属医院体检中心的50例健康体检者为对照组,年龄(50.61±9.47)岁。检测促甲状腺激素与血同型半胱氨酸等指标,并进行相关分析。结果1.T2DM患者HCY水平高于正常人(P0.05)。2.T2DM患者三组TSH间HCY差异有统计学意义,TSH水平与HCY水平呈正相关(P0.05)。3.HCY水平同T2DM及其慢性并发症呈正相关(P0.05)。4.T2DM患者HCY与Hb A1c(糖化血红蛋白)、甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白(LDL-C)呈正相关(P0.05),与高密度脂蛋白(HDL-C)呈负相关(P0.05)。结论1.2型糖尿病病患者血清中TSH变化与HCY、血管并发症呈正相关,提示未合并甲状腺疾病的2型糖尿病患者,在甲状腺激素水平正常情况下随着TSH水平的升高发生血管并发症的风险增加,TSH可能是2型糖尿病患者发生血管病变的危险因素之一。2.2型糖尿病病患者血清中TSH变化与糖、脂代谢相关,提示TSH变化与血糖、血脂、HCY互为因果,监测TSH、HCY有助于了解2型糖尿病患者的病情及预后。
[Abstract]:Objective to investigate the relationship between serum thyrotropin (TSH) and homocysteine (HCY) in patients with type 2 diabetes mellitus (T2DM). Methods from December 2012 to April 2014, 200 patients with T2DM in the Department of Endocrinology, second affiliated Hospital of Ningxia Medical University, were collected as diabetic group. The age was 55 卤15 years, the course of disease was 5.4 卤3.7 years, including 88 male patients and 112 female patients. According to the thyroid stimulating hormone (TSH) level, 200 patients with type 2 diabetes mellitus without thyroid disease were divided into 33 cases of TSH 0.3 鈮，

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