慢性牙周炎血清超氧化物歧化酶和丙二醛水平与2型糖尿病相关性的研究

发布时间：2018-03-01 07:38

本文关键词： 氧化应激 2型糖尿病慢性牙周炎超氧化物歧化酶丙二醛　出处：《南昌大学》2015年硕士论文　论文类型：学位论文

【摘要】：目的:本实验通过检测和比较慢性牙周炎(chronic periodontitis,CP)与2型糖尿病(type 2 diabetes mellitus,T2DM)患者血清丙二醛(malondialdehyde,MDA)和超氧化物歧化酶(superoxide dismutase,SOD)水平,以期探讨慢性牙周炎与2型糖尿病的相关性。方法:本实验采用病例对照研究,选取慢性牙周炎患者20例(牙周炎组),2型糖尿病患者23例(糖尿病组),慢性牙周炎合并2型糖尿病患者24例(牙周炎合并糖尿病组),健康对照者21例(健康组)。检测并比较各组牙周袋深度(probing depth,PD),附着丧失(attachment level,AL)、探诊出血(bleeding on probing,BOP)、糖化血红蛋白(HbA1c)、空腹血糖(FPG)、甘油三酯(TG)、总胆固醇(TCH)、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)、丙二醛和超氧化物歧化酶水平。所得数据计量资料以均数±标准差表示,多组间比较采用单因素方差分析,若有差异,进一步采用LSD检验;计数资料的比较使用卡方检验。结果:1、各组牙周临床指标:牙周炎组、牙周炎合并糖尿病组分别与糖尿病组、健康组相比,各牙周临床指标明显偏高;而牙周炎组与牙周炎合并糖尿病组之间牙周临床指标无统计学差异。2、生化指标的比较:(1)各组甘油三酯、总胆固醇、低密度脂蛋白水平无统计学差异。(2)牙周炎组糖化血红蛋白、空腹血糖、高密度脂蛋白水平与健康组无统计学差异。(3)糖尿病组和牙周炎合并糖尿病组的糖化血红蛋白、空腹血糖水平高于牙周炎组和健康组,有统计学差异;糖尿病组和牙周炎合并糖尿病组高密度脂蛋白低于健康组,有统计学差异;糖尿病组与牙周炎合并糖尿病组之间糖化血红蛋白、空腹血糖、高密度脂蛋白水平无统计学差异。3、各组丙二醛(MDA)和超氧化物歧化酶(SOD)水平的比较:糖尿病组、牙周炎合并糖尿病组血清MDA和SOD水平明显高于牙周炎组、健康组,差异有统计学意义,其中糖尿病组MDA和SOD水平最高,健康组MDA水平最低,牙周炎组SOD水平最低。4、丙二醛(MDA)、超氧化物歧化酶(SOD)与其他临床指标之间直线相关性分析:丙二醛与超氧化物歧化酶、糖化血红蛋白、空腹血糖、甘油三酯和年龄呈正相关关系,与牙周袋深度和牙周附着丧失无相关关系。超氧化物歧化酶与丙二醛、糖化血红蛋白、空腹血糖和年龄呈正相关关系,与高密度脂蛋白、牙周袋深度和牙周附着丧失呈负相关关系。结论:1、2型糖尿病患者和慢性牙周炎合并2型糖尿病患者血清MDA、SOD水平较慢性牙周炎患者高。2、在所有受试者中血清MDA水平与SOD、糖化血红蛋白、空腹血糖、甘油三酯和年龄呈正相关关系。3、在所有受试者中血清SOD水平与糖化血红蛋白、空腹血糖和年龄呈正相关,与高密度脂蛋白、牙周袋深度、牙周附着丧失呈负相关关系。
[Abstract]:Objective: to detect and compare the serum levels of malondialdehyde (MDA) and superoxide dismutase (SOD) in patients with chronic periodontitis and type 2 diabetes mellitus (type 2 diabetes mellitusus T2DM). Methods: a case-control study was conducted to investigate the relationship between chronic periodontitis and type 2 diabetes mellitus. Twenty patients with chronic periodontitis (23 patients with type 2 diabetes in periodontitis group), 24 patients with chronic periodontitis with type 2 diabetes mellitus (periodontitis combined with diabetes mellitus) and 21 healthy controls (healthy group) were selected. Detection and comparison of periodontal pouch depth probing, attachment level ALP, bleeding on probing BOP, glycosylated hemoglobin (HbA1cN), fasting blood glucose (FBG), triglyceride (TGN), total cholesterol (TCHC), high density lipoprotein (HDL), low density lipoprotein (LDL), malondialdehyde (MDA) and superoxide (O). Level of dismutase. Measured data are expressed as mean 卤standard deviation. Single factor analysis of variance (ANOVA) was used for multigroup comparison, LSD test was used for further analysis of variance, and chi-square test was used for the comparison of counting data. Results: the periodontal clinical indexes in each group: periodontitis group, periodontitis combined with diabetes group and diabetic group, respectively. There was no significant difference in periodontal clinical indexes between the periodontitis group and the periodontitis combined with diabetes group, and the comparison of biochemical indexes between the periodontitis group and the periodontitis combined with diabetes group was compared with that of the control group. There was no significant difference in low density lipoprotein (LDL-C) levels between the periodontitis group and the healthy group. There was no significant difference in glycosylated hemoglobin, fasting blood glucose and high density lipoprotein level between the diabetic group and the periodontitis with diabetes group. The level of fasting blood glucose was higher than that of periodontitis group and healthy group (P < 0.01), and the high density lipoprotein (HDL) level in diabetes group and periodontitis complicated diabetes group was lower than that in healthy group (P < 0.05). There was no significant difference in glycosylated hemoglobin, fasting blood glucose and high density lipoprotein levels between diabetic group and periodontitis complicated with diabetes group. The comparison of MDAs and SOD levels of malondialdehyde (MDA) and superoxide dismutase (SOD) in each group: diabetic group, The serum MDA and SOD levels in periodontitis with diabetes group were significantly higher than those in periodontitis group, and the difference was statistically significant in healthy group. The levels of MDA and SOD in diabetes group were the highest, and MDA level in healthy group was the lowest. In periodontitis group, the level of SOD was the lowest. 4, malondialdehyde (MDA) and superoxide dismutase (SOD) were correlated with other clinical indexes: malondialdehyde (MDA) and superoxide dismutase (SOD), glycosylated hemoglobin (HbHb), fasting blood glucose (FBG), triglyceride (TG) were positively correlated with age. Superoxide dismutase (SOD) was positively correlated with malondialdehyde (MDA), glycosylated hemoglobin (HbHb), fasting blood glucose (FBG) and age, but positively correlated with high density lipoprotein (HDL). Conclusion the serum MDA-SOD levels in patients with type 1 diabetes mellitus and chronic periodontitis with type 2 diabetes mellitus are higher than those in patients with chronic periodontitis, and the levels of serum MDA in all subjects are significantly higher than those in patients with chronic periodontitis. With SOD, glycosylated hemoglobin, Fasting blood glucose, triglyceride and age were positively correlated. In all subjects, serum SOD levels were positively correlated with glycosylated hemoglobin, fasting blood glucose and age, high density lipoprotein, periodontal pocket depth. There was a negative correlation between periodontal attachment loss and periodontal attachment loss.
【学位授予单位】：南昌大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R781.42;R587.1

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