营养综合干预对女性代谢综合征患者症状体征的影响

发布时间：2018-03-02 14:51

本文选题：代谢综合征　切入点：膳食纤维　出处：《山西医科大学》2015年硕士论文　论文类型：学位论文

【摘要】：目的:本研究通过观察营养综合干预及膳食纤维(Dietary Fiber,DF)强化干预后患者症状、体征的变化,探索代谢综合征临床营养治疗的合理方案及自我管理模式。方法:选择未服用代谢综合征相关药物的70名18-60岁女性患者进行为期4个月的营养综合干预。随机分为2组组,各35人,失访3人。实验结束后常规干预组(对照组)33人,膳食纤维强化干预组34人。常规干预组进行饮食及运动干预,膳食纤维强化干预组除饮食、运动干预外给予含总膳食纤维30%的活化燕麦膳食纤维30g/d。根据个人情况为每位志愿者配制个性化食谱并配备计步器一台,每10天随访一次。分别于干预前,干预后2月,干预后4月进行体格检查、人体成分分析、血生化检测。结果:1.干预前,所有受试者能量摄入为(1935.9±179.8)kcal,实验期间平均能量摄入减少23.7%,均无不良反应及饥饿感。两组年龄构成、体格检查、人体成分分析、生化指标差异均无统计学意义(P0.05)。2.强化干预2个月后,干预组体重、体质指数、腰围、臀围、腰臀比与干预前比较降低幅度更大,差异均有统计学意义。干预组血脂指标除HDL-C(HighDensity Lipoprotein Cholesterol)差异没有统计学意义外,其他差异均有统计学意义(P0.05)。强化干预2个月后血糖及胰岛素水平与干预前相比差异均有统计学意义(P0.05)。3.干预4月后,两组比较,BMI(Body Mass Index)、腰围、腰臀比、体脂百分比、内脏脂肪指数、皮褶厚度差异均有统计学意义。两组比较,TC(Total Cholesterol)、LDL-C(Low Density Lipoprotein Cholesterol)差异有统计学意义。两组比较,干预后餐后2h血糖差异有统计学意义(P0.05)。结论:膳食纤维强化干预可有效促进减肥,改善脂肪分布及血糖、血脂指标。本实验尚不能证明膳食纤维强化可有效改善血尿酸及胰岛素水平。饮食、运动及膳食纤维强化干预的模式适合于代谢综合征的临床治疗及患者的自我管理,值得推广应用。
[Abstract]:Objective: to observe the changes of symptoms and signs of patients after comprehensive nutrition intervention and dietary fiber reinforced intervention. Methods: 70 female patients aged 18-60 years without taking metabolic syndrome-related drugs were selected for 4 months of comprehensive nutrition intervention, and were randomly divided into two groups. After the experiment, the routine intervention group (33 cases in the control group and 34 cases in the dietary fiber intensive intervention group) were treated with diet and exercise intervention, and the dietary fiber reinforced intervention group with the exception of diet. In addition to exercise intervention, activated oat dietary fiber containing total dietary fiber 30% was given 30 g / d. Individualized diet was prepared for each volunteer and a pedometer was provided to each volunteer according to personal situation, followed up every 10 days. Before intervention, February after intervention, each patient was followed up. Results: before intervention, the energy intake of all subjects was 1935.9 卤179.8 kcal, and the average energy intake decreased by 23.7g / kg during the experiment period. There was no adverse reaction and hunger in the two groups. There was no significant difference in physical examination, body composition analysis and biochemical index. After 2 months of intensive intervention, the body weight, body mass index, waist circumference, hip circumference, waist-to-hip ratio in the intervention group were significantly lower than those before the intervention. There was no significant difference in blood lipid index except HDL-C(HighDensity Lipoprotein Cholesterolol in the intervention group. There were significant differences in blood glucose and insulin levels between two months after intensive intervention and before intervention. After the intervention on April, the two groups were compared with each other in BMI body Mass index, waist circumference, waist-hip ratio, body fat percentage, visceral fat index. There were significant differences in the thickness of skinfold between the two groups. The difference between the two groups was statistically significant. Conclusion: the dietary fiber intensive intervention can effectively promote weight loss, and the difference of 2 h postprandial blood glucose between the two groups is statistically significant (P 0.05). Improve the fat distribution, blood glucose, blood lipid index. This experiment can not prove that dietary fiber strengthening can effectively improve the levels of serum uric acid and insulin. The pattern of exercise and dietary fiber intensive intervention is suitable for the clinical treatment of metabolic syndrome and self-management of patients, so it is worth popularizing and applying.
【学位授予单位】：山西医科大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R589

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