单药多西他赛与多西他赛联合顺铂治疗胸腺瘤合并重症肌无力的临床疗效研究

发布时间：2018-03-05 08:07

本文选题：胸腺肿瘤　切入点：重症肌无力　出处：《中国全科医学》2017年30期 　论文类型：期刊论文

【摘要】：目的探讨单药多西他赛与多西他赛联合顺铂治疗胸腺瘤合并重症肌无力(MG)的临床疗效,以期为临床医生提供新的治疗思路。方法选取2008年1月—2015年12月就诊于石家庄市第一医院的明确诊断为胸腺瘤合并MG患者106例。2008年1月—2015年1月应用多西他赛联合顺铂治疗的胸腺瘤合并MG患者(DP组)66例,包括20例胸腺瘤术后出现转移胸腺瘤患者;2012年1月—2015年12月应用单药多西他赛治疗胸腺瘤合并MG患者(D组)40例,包括17例胸腺瘤术后出现转移胸腺瘤患者。两组分别给予相应药物治疗,比较两组患者治疗前后临床绝对评分、乙酰胆碱受体抗体(AchRAb)、MG临床疗效、毒副作用发生情况。结果两组治疗前临床绝对评分、AchRAb比较,差异无统计学意义(P0.05)。两组治疗后临床绝对评分、AchRAb比较,差异无统计学意义(P0.05)。两组治疗后临床绝对评分、AchRAb低于治疗前(P0.05)。两组MG临床疗效比较,差异无统计学意义(P0.05)。DP组患者毒副作用发生率高于D组(P0.05)。结论单药多西他赛与多西他赛联合顺铂治疗胸腺瘤合并MG患者的疗效无差异,但单药多西他赛的毒副作用小。
[Abstract]:Objective to investigate the clinical effect of single drug docetaxel and docetaxel combined with cisplatin in the treatment of thymoma with myasthenia gravis. Methods from January 2008 to December 2015, 106 patients with thymoma complicated with MG were selected from the first Hospital of Shijiazhuang City. Docetaxel was used from January 2008 to January 2008. 66 cases of thymoma combined with MG were treated with cisplatin in DP group. From January 2012 to December 2015, 40 patients with thymoma complicated with MG were treated with single drug docetaxel. There were 17 patients with metastatic thymoma after thymoma operation. The two groups were treated with corresponding drugs respectively. The absolute score of patients before and after treatment and the clinical efficacy of acetylcholine receptor antibody AchRAbmG were compared between the two groups. Results there was no significant difference in the absolute clinical score before treatment between the two groups (P 0.05). There was no significant difference between the two groups (P 0.05). After treatment, the absolute clinical score of AchRAb was lower in the two groups than that in the control group (P 0.05). The clinical efficacy of MG was compared between the two groups. There was no significant difference in the incidence of side effects between the two groups. Conclusion there is no difference in the efficacy of single drug docetaxel and docetaxel combined with cisplatin in the treatment of thymoma with MG, but the side effect of single drug docetaxel is small.
【作者单位】：河北省石家庄市第一医院重症肌无力诊疗中心;
【基金】：河北省自然科学基金资助项目(H2015106020) 石家庄市科技局指导项目(131460613) 河北省科技计划项目(14277758D) 河北省中医药管理局项目(2014221)
【分类号】：R736.3;R746.1

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