钙通道和细胞内钙信号对小肠葡萄糖吸收的调节作用及机制

发布时间：2018-03-06 03:29

本文选题：葡萄糖吸收　切入点：钙离子通道　出处：《中国糖尿病杂志》2017年05期 　论文类型：期刊论文

【摘要】：迄今为止葡萄糖在小肠黏膜的吸收机制已被系统地阐明和接受,即经典的钠葡萄糖同向转运体(SGLT1)介导的主动转运机制。此外,当肠腔葡萄糖浓度高于SGLT1的转运饱和度时,葡萄糖转运蛋白2(GluT2)可能一过性易位于小肠黏膜上皮细胞顶膜来参与葡萄糖的异化扩散吸收,但小肠黏膜上皮细胞葡萄糖吸收的调节机制仍然不是完全清楚。近年来钙离子通道(CRAC)及细胞内钙信号对葡萄糖的吸收调节作用备受关注,二者可通过调节肠道葡萄糖转运体SGLT1和GluT2的表达及功能来调节小肠葡萄糖的吸收。本文以CRAC及细胞内钙信号对小肠黏膜上皮细胞葡萄糖的吸收调节作用及其分子机制进行论述,希望能为肥胖及其相关疾病的防治提供新的视野及潜在的新药研发靶点。
[Abstract]:Up to now, the mechanism of glucose absorption in intestinal mucosa has been systematically elucidated and accepted, that is, the classical mechanism of active transport of sodium and glucose to the transporter SGLT1. In addition, when the concentration of glucose in intestinal cavity is higher than the saturation of transport of SGLT1, Glucose transporter 2 (GluT2) may be temporarily located in the apical membrane of small intestinal mucosal epithelium to participate in the dissimilatory diffusion and absorption of glucose. However, the regulation mechanism of glucose absorption in intestinal mucosal epithelial cells is still not fully understood. In recent years, the regulation of glucose absorption by intracellular calcium signal and calcium channel (CRAC) has attracted much attention. They can regulate the absorption of glucose by regulating the expression and function of intestinal glucose transporter SGLT1 and GluT2. In this paper, we discuss the regulation of glucose absorption by CRAC and intracellular calcium signal and its molecular mechanism. Hope to provide a new vision and potential new drug development targets for the prevention and treatment of obesity and related diseases.
【作者单位】：遵义医学院附属医院消化内科;
【基金】：国家自然科学基金(31371167、No81570、81570477)
【分类号】：R589.2

【相似文献】