复方番石榴制剂对超重肥胖2型糖尿病患者胰岛素抵抗影响的临床研究

发布时间：2018-03-08 23:25

本文选题：复方番石榴制剂　切入点：超重　出处：《时珍国医国药》2016年11期 　论文类型：期刊论文

【摘要】：目的研究复方番石榴制剂对超重肥胖2型糖尿病患者胰岛素抵抗的影响。方法选取广州中医药大学附属中山医院诊治的超重肥胖2型糖尿病患者120例,将入组患者随机分为2组,治疗组予复方番石榴制剂联合二甲双胍肠溶片,对照组予二甲双胍肠溶片,两组均用药12周,于治疗前、治疗12周后分别记录其空腹血糖(FBG)、餐后2h血糖(P2BG)、糖化血红蛋白(Hb A1c)、胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C)、脂联素(APN)、C-反应蛋白(CRP)、空腹胰岛素(FINS)等指标,根据公式计算患者胰岛素分泌指数(HOMA-β),并对以上指标进行统计学分析。结果治疗组治疗后FBG、P2BG、Hb A1c、TC、TG、LDL-C、CRP较治疗前明显下降(P0.05);两组比较,治疗12周后治疗组患者的FBG、P2BG、Hb A1c、TC、TG、LDL-C与对照组比较有显著性差异(P0.05),但CRP与对照组比较无显著性差异(P0.05);治疗后,两组的FINS、HOMA-β、APN均有一定程度的上升,治疗组治疗前后比较,差异有统计学意义(P0.05),两组治疗后比较,差异亦有统计学意义(P0.05)。结论复方番石榴制剂联合二甲双胍具有较好的降糖、降脂作用,且能改善胰岛素抵抗。其对脂联素水平的调控可能是纠正胰岛素抵抗的重要机制。
[Abstract]:Objective to study the effect of compound guava preparation on insulin resistance in patients with type 2 diabetes mellitus. Methods 120 patients with type 2 diabetes mellitus were selected from Zhongshan Hospital affiliated to Guangzhou University of traditional Chinese Medicine. Patients in the treatment group were randomly divided into two groups: the treatment group was treated with compound guava and metformin enteric-coated tablets, the control group was given metformin enteric-coated tablets, and the two groups were treated with metformin enteric-coated tablets for 12 weeks. After 12 weeks of treatment, fasting blood glucose (FBGG), 2h postprandial blood glucose (P2BGN), glycosylated hemoglobin (HbA1cN), cholesterol triglyceride (TCN), triglyceride (TG), low density lipoprotein (LDL-C), high density lipoprotein (HDL-C), adiponectin (APNAPNC-reactive protein) (CRPN), fasting insulin (FINS), and so on were recorded, respectively. According to the formula, the insulin secretion index (HOMA- 尾) of patients was calculated, and the above indexes were analyzed statistically. After 12 weeks of treatment, there was a significant difference in LDL-C between the two groups (P 0.05), but there was no significant difference between the CRP and the control group (P 0.05). After treatment, the FINSHOMA- 尾 APN of the two groups were increased to a certain extent, compared with those of the control group, and the difference between the two groups before and after treatment was not significant (P < 0.05), but there was no significant difference between the treatment group and the control group (P < 0.05), but there was no significant difference between the two groups before and after treatment, and there was no significant difference between the two groups before and after treatment. The difference was statistically significant (P 0.05), and the difference was also statistically significant after treatment. Conclusion compound guava preparation combined with metformin has better hypoglycemic and lipid-lowering effects. The regulation of adiponectin level may be an important mechanism to correct insulin resistance.
【作者单位】：广州中医药大学附属中山医院;
【基金】：广东省中医药局立项资助项目(No.20141282) 广东省中山市科技局重点资助项目(No.2014A1FC004)
【分类号】：R587.1;R589.2

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