环境双酚A暴露与人群糖尿病关系的meta分析

发布时间：2018-03-10 00:16

本文选题：双酚A　切入点：糖尿病　出处：《环境与健康杂志》2017年07期 　论文类型：期刊论文

【摘要】：目的探讨环境双酚A(BPA)暴露与人群糖尿病的关系。方法以计算机检索中外期刊数据库[包括中国学术期刊全文数据库(CNKI)、万方数据知识服务平台全文数据库、维普中文科技期刊全文数据库(VIP)、Pub Med、EBSCO、Elsevier Science direct、Medical Evidence Matters Archive],收集各数据库从建库至2016年4月有关BPA暴露对糖尿病患病影响公开发表的文献。按照文献纳入排除标准筛选文献后进行meta分析。结果最终纳入9篇文献共10个研究。meta分析结果显示整体合并效应值OR为1.32(95%CI:1.15~1.52,P0.01);2型糖尿病、妊娠期糖尿病以及不区分糖尿病类型三组研究进行亚组分析,各自合并OR值分别为1.19(95%CI:0.99~1.42)、0.70(95%CI:0.27~1.79)以及1.80(95%CI:1.39~2.34),结合漏斗图和Egger回归分析(P=0.691)发现纳入文献不存在发表偏倚。结论较高BPA暴露可增加整体糖尿病的患病风险,但对不同类型糖尿病作用可能存在差异。
[Abstract]:Objective to explore the relationship between exposure to environmental bisphenol A (BPA) and diabetes mellitus in population. Methods Chinese and foreign journal databases were searched by computer. The full text database of Weip Chinese scientific and technological journals, Pub Med#en0# Elsevier Science direct medical Evidence Matters Archive, collected the literature published from the establishment of the database to April 2016 on the influence of BPA exposure on diabetes mellitus. The literature was screened according to the exclusion criteria. Meta analysis was carried out. The results of 10 studies and meta analysis showed that the overall combined effect value was 1.3295% CI: 1.15 / 1.52% (P 0.01) and type 2 diabetes mellitus (T2DM). The subgroup analysis of gestational diabetes mellitus (GDM) and the three groups without distinguishing the type of diabetes mellitus (GDM) was carried out. Their combined OR values were 1.19 / 95 CI: 0.991.42 / 0.7095 (CI: 0.271.79) and 1.80 / 95CI: 1.392.34 (combined with funnel chart and Egger regression analysis P0.691). Conclusion there is no publication bias in the literature included in the study. Conclusion higher BPA exposure can increase the risk of diabetes mellitus as a whole. But there may be differences in the effects on different types of diabetes.
【作者单位】：中国疾病预防控制中心环境与健康相关产品安全所;
【分类号】：R587.1

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