SF、VAP-1在慢性酒精中毒及急性脑梗死患者中检测的临床意义

发布时间：2018-03-10 20:15

本文选题：血清铁蛋白　切入点：血管粘附蛋白-1　出处：《延边大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:探讨血清铁蛋白、血管粘附蛋白-1在慢性酒精中毒及急性脑梗死中检测的意义,研究其变化趋势,同时对患者的中性粒细胞百分比及红细胞分布宽度进行测定,为疾病的早期诊断、治疗与预后改善提供。方法:选取慢性酒精中毒患者25例,诊断符合CCMD-3修订的酒精所致精神障碍诊断标准;急性脑梗死组患者25例,患者全部由头部MRI证实存在急性梗死病灶;正常对照组20例。实验采用ELISA双抗体夹心法测定血清铁蛋白及血管粘附蛋白-1水平;采用全自动血细胞分析仪测定中性粒细胞百分比及红细胞分布宽度。结果:1.慢性酒精中毒患者SF水平(294.3 ±92.5)ng/ml高于正常对照组(112.4±64.8)ng/ml,差异有显著性(P0.05);VAP-1水平(178.9±33.8)ng/ml高于正常对照组(111.7±14.1)ng/ml,差异有显著性(P0.05);中性粒细胞百分比(%)57.7±11.1和正常对照组53.6±3.6比较差异无统计学意义(P05);红细胞分布宽度(fl)46.4±3.2高于正常对照组40.6±2.1,有显著差异(P0.05)。2.急性脑梗死患者SF水平(347.3 ±60.3)ng/ml高于正常对照组(112.4±64.8)ng/ml,差异有显著性(P0.05);VAP-1水平(i83.3±50.8)ng/ml 高于正常对照组(111.7±14.1)ng/ml,差异有显著性(P0.05);中性粒细胞百分比(%)61.9±12.9和正常对照组比较53.6±3.6比较有显著差异(P0.05);红细胞分布宽度(fl)47.3±4.1,高于正常对照组40.6±2.1,有显著差异(P0.05)。结论:1.慢性酒精中毒患者SF、VAP-1水平升高,可能是慢性酒精中毒诊断的参考指标,SF、VAP-1参与发病过程,可能对慢性酒精中毒的治疗有一定帮助。2.急性脑梗死者SF、VAP-1 平升高,在急性脑梗死的发病机制中有参与,可能对急性脑梗死干预有临床意义。
[Abstract]:Objective: to investigate the significance of detection of serum ferritin and vascular adhesion protein-1 in patients with chronic alcoholism and acute cerebral infarction. Methods: 25 patients with chronic alcoholism, 25 patients with chronic alcoholism, 25 patients with acute cerebral infarction, 25 patients with acute cerebral infarction, were selected for early diagnosis, treatment and prognosis improvement. Acute infarct lesions were confirmed by head MRI and 20 normal controls. Serum ferritin and vascular adhesion protein-1 levels were measured by ELISA double antibody sandwich method. The percentage of neutrophils and the distribution width of erythrocytes were measured by automatic blood cell analyzer. Results: 1. The SF level of chronic alcoholism patients was 294.3 卤92.5 ng / ml higher than that of normal controls (112.4 卤64.8 ng / ml), and the difference was significant (P 0.05) VAP-1 level was 178.9 卤33.8 ng / ml higher than that of normal controls. The percentage of neutrophils was 57.7 卤11.1 and 53.6 卤3.6 in the control group respectively. The distribution width of red blood cells was 46.4 卤3.2 higher than that of the normal control group (40.6 卤2.1). The SF level of acute cerebral infarction patients was 347.3 卤60.3ng / ml. The level of VAP-1 was significantly higher than that of the normal control group (112.4 卤64.8ng / ml), and the level of VAP-1 was 83.3 卤50.8ng / ml higher than that of the normal control group (111.7 卤14.1 ng / ml), the percentage of neutrophils was significantly higher than that of the normal control group (53.6 卤3.6), the percentage of neutrophils was significantly higher than that of the normal control group (53.6 卤3.6), and the distribution width of red blood cells was 47.3 卤4.1, which was higher than that of the normal control group (P < 0.05). There was a significant difference between normal control group (40.6 卤2.1) and control group (P 0.05). Conclusion the level of VAP-1 in patients with chronic alcoholism is higher than that in control group (P < 0.05). It may be a reference index for the diagnosis of chronic alcoholism. SFAP-1 may be involved in the pathogenesis of chronic alcoholism, and it may be helpful to the treatment of chronic alcoholism. 2. The level of VAP-1 in patients with acute cerebral infarction is increased, and it is involved in the pathogenesis of acute cerebral infarction. It may have clinical significance for the intervention of acute cerebral infarction.
【学位授予单位】：延边大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R595.6;R743.33

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