雷公藤多苷片联合泼尼松对风湿性多肌痛患者的疗效及血浆、免疫蛋白的影响分析

发布时间：2018-03-11 04:00

本文选题：风湿性多肌痛　切入点：雷公藤多苷片　出处：《中国地方病防治杂志》2017年04期 　论文类型：期刊论文

【摘要】：目的探讨雷公藤多苷片联合泼尼松治疗风湿性多肌痛患者的临床疗效,并对血浆、免疫蛋白进行分析。方法将86例风湿性多肌痛患者随机分为观察组和对照组,每组43例。观察组给予雷公藤多苷片联合泼尼松治疗,对照组仅给予泼尼松片治疗。比较两组患者的临床疗效;并测定患者红细胞沉降率、C反应蛋白、血红蛋白、血小板及血清免疫球蛋白的情况。结果观察组临床有效率为90.70%,对照组临床有效率为58.14%,两组临床疗效相比,差异具有统计学显著性(P0.05);观察组治疗后与治疗前PMR-AS相比,差异具有统计学意义(P0.01),对照组治疗后与治疗前PMR-AS相比,差异具有统计学显著性(P0.05),治疗后,观察组PMR-AS显著低于对照组(P0.05);治疗后,两组患者的红细胞沉降率、C反应蛋白、血小板、血清免疫球蛋白水平显著低于治疗前(P0.05),血红蛋白水平显著高于治疗前(P0.05);且治疗后,观察组患者的各项检测指标水平与对照组相比,差异具有统计学意义(P0.01)。两组不良反应发生率相比,差异具有统计学意义(P0.05)。结论雷公藤多苷片联合泼尼松治疗风湿性多肌痛的疗效优于单独给予泼尼松,对患者血浆红细胞沉降率、血清免疫球蛋白、C反应蛋白、血小板有降低的作用,对血红蛋白有升高的作用。
[Abstract]:Objective to investigate the clinical effect of Tripterygium wilfordii polyglycoside tablets combined with prednisone in the treatment of rheumatic polymyalgia, and to analyze the plasma and immune proteins. Methods 86 patients with rheumatic polymyalgia were randomly divided into observation group and control group. 43 patients in each group were treated with tripterygium wilfordii polyglycoside tablets combined with prednisone, while the control group were treated with prednisone tablets only. Results the effective rate of platelet and serum immunoglobulin was 90.70 in the observation group and 58.14 in the control group. The difference between the two groups was statistically significant (P 0.05). The difference was statistically significant (P 0.01). Compared with pre-treatment PMR-AS, the difference was statistically significant in the control group (P 0.05). After treatment, the PMR-AS in the observation group was significantly lower than that in the control group (P 0.05), the erythrocyte sedimentation rate of the two groups was significantly lower than that of the control group (P 0.05), and the erythrocyte sedimentation rate of the two groups was significantly lower than that of the control group (P 0.05). The serum immunoglobulin level was significantly lower than that before treatment, and the hemoglobin level was significantly higher than that before treatment. The difference was statistically significant in the incidence of adverse reactions between the two groups. Conclusion Tripterygium wilfordii polyglycoside combined with prednisone is more effective than prednisone alone in the treatment of rheumatic polymyalgia. The erythrocyte sedimentation rate, serum immunoglobulin C reactive protein and platelet were decreased and hemoglobin was increased.
【作者单位】：川北医学院;川北医学院附属医院;
【基金】：卓越医师实验班实践教学体系的构建与研究(项目编号:15-12-24)
【分类号】：R593.2

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