代谢手术对2型糖尿病患者认知功能影响研究

发布时间：2018-03-11 09:49

本文选题：代谢手术　切入点：型糖尿病　出处：《中国实用内科杂志》2017年01期 　论文类型：期刊论文

【摘要】：目的研究代谢手术对2型糖尿病患者认知功能的影响。方法选取2015年4月至2016年6月第三军医大学大坪医院住院的65例2型糖尿病患者,其中行代谢手术的患者30例,未行手术治疗的患者35例,分别完成体检、实验室检查、认知功能量表评估,并对两组患者一般资料及认知功能进行统计分析。结果在校正两组患者一般资料之前,在总体认知功能评价、记忆力与执行力、语言流畅性、视觉空间能力方面,手术组优于非手术组(P0.05),在注意力与定向力方面,两组差异无统计学意义(P0.05);在校正两组患者一般资料之后,在记忆力、执行力、语言流畅性方面,手术组优于非手术组(P0.05);在总体认知功能评价、注意力与定向力、视觉空间能力方面,两组差异无统计学意义(P0.05)。两组患者的认知功能与体重指数、血压、血糖、血脂及高敏C反应蛋白无相关性。结论代谢手术能改善糖尿病患者认知功能,且其机制可能独立于糖尿病患者体重、血压、糖脂代谢的改善。
[Abstract]:Objective to study the effect of metabolic surgery on the cognitive function of type 2 diabetic patients. Methods Sixty-five patients with type 2 diabetes were selected from Daping Hospital of the third military Medical University from April 2015 to June 2016, including 30 patients undergoing metabolic surgery. 35 patients without surgical treatment completed physical examination, laboratory examination, cognitive function scale evaluation, and statistical analysis of the general data and cognitive function of the two groups. Results before correcting the general data of the two groups of patients, In general cognitive function evaluation, memory and executive ability, language fluency and visual spatial ability, the operation group was superior to the non-operative group in terms of attention and orientation. There was no significant difference between the two groups (P 0.05). After correcting the general data of the two groups, the operation group was superior to the non-operative group in memory, executive ability and language fluency, and in the overall cognitive function evaluation, attention and orientation. There was no significant difference in visual spatial ability between the two groups (P 0.05). There was no correlation between cognitive function and body mass index, blood pressure, blood glucose, blood lipids and Gao Min C-reactive protein. Conclusion Metabolic surgery can improve the cognitive function of diabetic patients. The mechanism may be independent of the improvement of body weight, blood pressure, glucose and lipid metabolism in diabetic patients.
【作者单位】：第三军医大学附属第三医院野战外科研究所高血压内分泌科;第三军医大学附属第三医院野战外科研究所胃结直肠外科;
【基金】：国家自然科学基金(91339112)
【分类号】：R587.1;R656.6

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