雾化吸入呋塞米辅助治疗支气管哮喘疗效和安全性的Meta分析

发布时间：2018-03-11 11:12

本文选题：呋塞米　切入点：支气管哮喘　出处：《中国药房》2017年12期 　论文类型：期刊论文

【摘要】：目的:系统评价雾化吸入呋塞米辅助治疗支气管哮喘的疗效与安全性,为临床治疗提供循证参考。方法:计算机检索Pub Med、Cochrane图书馆、相关期刊论文、万方数据库、中文科技期刊数据库,收集在常规治疗的基础上,雾化吸入呋塞米(试验组)对比常规方案(对照组)治疗支气管哮喘的随机对照试验(RCT),按Cochrane系统评价员手册5.1.0推荐的方法进行资料提取和质量评价,采用Rev Man 5.3统计软件进行Meta分析。结果:共纳入13项RCT,合计708例患者。Meta分析结果显示,试验组患者显效率[RR=1.53,95%CI(1.28,1.84),P0.001]、总有效率[RR=1.34,95%CI(1.23,1.45),P0.001]、咽部不适发生率[RR=10.79,95%CI(1.47,78.99),P=0.02]、胃肠道不良反应发生率[RR=10.80,95%CI(1.43,81.53),P=0.02]均显著高于对照组,差异均有统计学意义。两组患者口干发生率[RR=3.71,95%CI(0.81,16.86),P=0.09]和电解质紊乱发生率[RR=2.38,95%CI(0.10,56.53),P=0.59]比较,差异均无统计学意义。结论:在常规治疗基础上,雾化吸入呋塞米辅助治疗支气管哮喘疗效与安全性均较好,但临床使用应重点观察患者咽部和胃肠道不良反应。
[Abstract]:Objective: to evaluate the efficacy and safety of atomized furosemide in the treatment of bronchial asthma, and to provide evidence based reference for clinical treatment. Methods: the Pub Medsite Cochrane Library, the full text Database of Chinese Journal and the Wanfang Database were searched by computer. The database of Chinese science and technology periodicals, which is collected on the basis of routine treatment, Aerosol inhaled furosemide (test group) was used to extract the data and evaluate the quality of Cochrane system evaluator's manual 5.1.0 in the randomized controlled trial of bronchial asthma treated with routine regimen (control group). Meta analysis was carried out with Rev Man 5.3 software. Results: a total of 13 RCTs were included, and a total of 708 patients. Meta-analysis results showed that, The effective rate of patients in the trial group was 1.281.281.84 / P0.001, the total effective rate was 1.231.45P0.001, the incidence of pharyngeal discomfort was 1.478.99P0.02, the incidence of gastrointestinal adverse reactions was significantly higher than that of the control group (P 0.02), the difference between the two groups was statistically significant. Conclusion: the efficacy and safety of furosemide inhalation in the treatment of bronchial asthma is good, but the adverse reactions of pharynx and gastrointestinal tract should be observed in clinical use.
【作者单位】：遵义医学院附属医院呼吸二科;
【基金】：贵州省科学技术基金资助项目(No.黔科合J字[2007]2218号)
【分类号】：R562.25

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