脐带间充质干细胞移植对强直性脊柱炎患者免疫调节及组织损伤的影响

发布时间：2018-03-13 02:13

本文选题：脊柱炎　切入点：强直性　出处：《中国组织工程研究》2016年01期 　论文类型：期刊论文

【摘要】：背景:间充质干细胞具有独特的免疫调节特性,使得其成为移植领域和治疗自身性免疫疾病的研究热点。目的:探讨脐带间质干细胞对强直性脊柱炎患者免疫水平以及组织损伤的影响。方法:回顾性分析61例强直性脊柱炎患者的临床资料,按照治疗方法分为对照组(33例)和观察组(28例),分别进行免疫及生物剂治疗、脐带间充质干细胞输注治疗。治疗结束后随访12个月,观察两组治疗效果、免疫学指标、病情活动指数评分和不良反应发生情况。结果与结论:(1)总有效率:观察组和对照组分别为89%和76%,经比较差异有显著性意义(P0.05)。(2)随访12个月,两组的血沉等指标均得到显著改善,且观察组均显著优于对照组(P0.05);两组病情活动指数评分均随着时间的推移不断下降,且治疗后3个月开始,观察组病情活动指数评分均显著低于对照组(P0.05)。(3)不良反应:观察组有1例患者在治疗过程中出现注射外渗现象,经重新选择血管后顺利完成注射。2例患者出现轻微发热现象,经积极物理降温之后体温恢复至正常水平。(4)结果表明,脐带间充质干细胞输注治疗强制性脊柱炎可以显著改善患者的免疫水平,并有效减轻组织损伤,不良反应较轻微。
[Abstract]:Background: mesenchymal stem cells (MSCs) have unique immunomodulatory properties. Objective: to investigate the effect of umbilical cord mesenchymal stem cells on the immune level and tissue damage in patients with ankylosing spondylitis. Methods: 61 cases of ankylosing spondylitis were retrospectively analyzed. Clinical data of patients with ankylosing spondylitis, According to the treatment method, 33 cases were divided into control group (n = 33) and observation group (n = 28), which were treated with immunological and biological agents, respectively, and were treated with umbilical cord mesenchymal stem cell infusion respectively. 12 months after treatment, the therapeutic effects and immunological indexes were observed. Results and conclusion the total effective rate was 89% and 76 in the observation group and the control group, respectively. There was significant difference between the two groups (P 0.05). The two groups were followed up for 12 months. The blood sedimentation rate of the two groups were significantly improved. The scores of disease activity index of the two groups decreased with time, and began 3 months after treatment, and the observation group was significantly better than the control group (P 0.05), and the scores of the disease activity index of the two groups were decreased with the passage of time. The scores of disease activity index in the observation group were significantly lower than those in the control group (P 0.05). The adverse reactions were as follows: one patient in the observation group had extravasation during the course of treatment, and a slight fever had occurred in .2 patients who had successfully completed the injection after re-selecting the blood vessel. The results showed that umbilical cord mesenchymal stem cell infusion could significantly improve the immune level of patients with mandatory spondylitis and effectively alleviate tissue injury.
【作者单位】：阆中市人民医院骨科;川北医学院附属医院骨科;
【分类号】：R593.23

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