黄连素治疗2型糖尿病研究进展

发布时间：2018-03-13 23:00

本文选题：黄连素　切入点：型糖尿病　出处：《中国中药杂志》2014年08期 　论文类型：期刊论文

【摘要】：黄连素是中药黄连的主要活性成分,一直被作为一种抗感染、抗炎症的药物用于胃肠道的疾病。近年来,许多研究表明黄连素具有调控糖脂代谢的作用,而这种活性已经被临床、动物以及体外细胞实验所证实。黄连素发挥治疗糖尿病改善胰岛素抵抵抗的机制主要包括:可以改善胰岛β细胞的功能,促进胰岛素的释放以及胰岛细胞的再生;具有降低甘油三酯、胆固醇的作用;抑制线粒体的功能,减少能量的产生;可激活AMPK信号通路,促进糖的代谢;通过调控和转录因子如PPARγ,C/EBPα,SREBP-1c,LXR等的表达,进而调控糖脂代谢;具有抗氧化并抑制还原反应的作用,从而抑制机体内的氧化应激状态,干预糖脂代谢的信号通路。其作为调控糖脂代谢的药物在尽管已经从临床和动物实验获得大量的支持黄连素具有调节糖脂代谢,改善胰岛素抵抗状态的证据,但是,在循证医学的时代仍然需要大规模的临床随机实验来评估黄连素对糖尿病及其并发症的疗效。
[Abstract]:Berberine, the main active component of Coptis chinensis, has been used as an anti-infective and anti-inflammatory drug for gastrointestinal diseases. In recent years, many studies have shown that berberine can regulate glycolipid metabolism. And this activity has been confirmed by clinical, animal and in vitro cell experiments. The mechanisms of berberine in improving insulin resistance in diabetes mellitus include improving the function of islet 尾 cells. Promoting insulin release and islet cell regeneration; reducing triglyceride and cholesterol; inhibiting mitochondrial function; reducing energy production; activating AMPK signaling pathway; promoting glucose metabolism; By regulating and regulating the expression of PPAR 纬 -C / EBP 伪 -SREBP-1cXR, thus regulating the metabolism of glucose and lipid, it has the function of antioxidation and inhibition of reduction reaction, thereby inhibiting the oxidative stress in the body. The signaling pathway that interferes with glycolipid metabolism. Although berberine has been extensively supported in clinical and animal trials to regulate glycolipid metabolism and improve insulin resistance, it has been used as a drug to regulate glycolipid metabolism. In the age of evidence-based medicine, large-scale randomized trials are still needed to assess the efficacy of berberine in the treatment of diabetes and its complications.
【作者单位】：黑龙江中医药大学附属第一医院;
【基金】：黑龙江中医药大学科研基金项目(201212) 黑龙江中医药大学博士后流动站课题项目(LRB12-407)
【分类号】：R587.1

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