糖尿病足患者足部创面感染的病原菌分布及药敏结果分析

发布时间：2018-03-14 05:16

本文选题：糖尿病足　切入点：感染　出处：《山东医药》2016年30期 　论文类型：期刊论文

【摘要】：目的分析糖尿病足感染患者足部创面的病原菌分布及药敏情况,指导临床合理用药。方法选择糖尿病足感染患者89例,对患者的足部创面采用无菌棉拭子旋转取样,进行菌株鉴定及药敏试验。结果 89例糖尿病足感染患者创面的分泌物中,有75例(84.27%)培养出病原菌,共培养出病原菌95株,其中革兰阳性菌50株(52.63%)、革兰阴性菌42株(42.21%)、真菌3株(3.16%),单一菌感染56例、混合菌感染19例。药敏结果示革兰阳性菌对万古霉素、利奈唑胺、替加环素、庆大霉素较为敏感,对青霉素、苯唑西林、红霉素、克林霉素有一定的耐药性;革兰阴性菌对亚胺培南、厄胺培南、氨基糖苷类和第二、三代头孢菌素及加β-内酰胺酶抑制剂的抗菌药物较为敏感,对第一代头孢菌素类耐药性高。结论糖尿病足感染患者足部创面病原菌主要为革兰阳性菌,其次为革兰阴性菌。革兰阳性菌对万古霉素、利奈唑胺、替加环素、庆大霉素敏感,革兰阴性菌对亚胺培南、厄胺培南、氨基糖苷类和第二、三代头孢菌素及加β-内酰胺酶抑制剂的抗菌药物较为敏感。
[Abstract]:Objective to analyze the distribution of pathogenic bacteria and drug sensitivity of foot wound in patients with diabetic foot infection, and to guide the rational use of drugs in clinic. Methods 89 patients with diabetic foot infection were selected and the foot wounds were sampled with aseptic cotton swab. Results of the 89 patients with diabetic foot infection, 75 cases were isolated from the wound surface and 95 strains were cultured. Among them, 50 strains of Gram-positive bacteria, 42 strains of Gram-negative bacteria, 3 strains of fungi, 56 cases of single bacteria and 19 cases of mixed bacteria were found to be sensitive to vancomycin, linazolamide, tegacyclin and gentamicin. Gram-negative bacteria were sensitive to imipenem, epimipenem, aminoglycoside, second and third generation cephalosporins and 尾 -lactamase inhibitors, and were resistant to penicillin, oxacillin, erythromycin and clindamycin, and Gram-negative bacteria were more sensitive to imipenem, erampenem, aminoglycoside and the second and third generation cephalosporins and 尾 -lactamase inhibitors. Conclusion the pathogenic bacteria in foot wound of diabetic foot infection patients are mainly Gram-positive bacteria, followed by Gram-negative bacteria. Gram-positive bacteria are sensitive to vancomycin, linazolamine, tegacycline, gentamicin, and so on. Gram-negative bacteria were sensitive to imipenem, erampenem, aminoglycosides, second and third generation cephalosporins and 尾 -lactamase inhibitors.
【作者单位】：安徽医科大学附属安徽省立医院;
【分类号】：R587.2

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