不同糖代谢状态下患者血浆醛固酮水平的差异

发布时间：2018-03-14 19:47

本文选题：醛固酮　切入点：血浆肾素活性　出处：《广东医学》2017年08期 　论文类型：期刊论文

【摘要】：目的评估不同糖代谢状态下血浆醛固酮(PAC)水平的差异,并通过回归分析探讨PAC与胰岛素抵抗之间的关系。方法根据既往病史和葡萄糖耐量试验(OGTT)结果将患者分为糖耐量减低组(IGT组)50例和糖尿病组(T2DM组)50例,体检中心收集正常糖代谢(NGT)组50例。通过检测血浆PAC、血浆肾素活性(PRA)、血糖和胰岛素,比较不同糖代谢状态下PAC和PRA的差异。通过logistic回归分析,筛选胰岛素抵抗的危险因素。结果 (1)T2DM组患者的PAC和PRA水平高于NGT组。(2)PAC与空腹胰岛素、HOMA-IR均呈正相关,相关系数分别为0.245(P0.01)和0.143(P=0.05)。(3)二项logistic回归分析提示BMI和PAC升高是胰岛素抵抗的危险因素,其OR值分别为8.596(95%CI:3.30~21.12,P0.001)和3.570(95%CI:1.01~11.77,P0.05)。结论 T2DM患者PAC和PRA水平均高于NGT患者,PAC升高是胰岛素抵抗的独立危险因素。
[Abstract]:Objective to evaluate the difference of plasma aldosterone (PAC-1) levels in different glucose metabolism states. The relationship between PAC and insulin resistance was studied by regression analysis. Methods according to the past history and the results of glucose tolerance test (OGTT), the patients were divided into two groups: 50 patients with impaired glucose tolerance and 50 patients with diabetes mellitus (T2DM). 50 patients with normal glucose metabolism (NGT) group were collected in the physical examination center. The plasma PAC, plasma renin activity, plasma glucose and insulin were measured, and the differences of PAC and PRA in different glucose metabolic states were compared by logistic regression analysis. Results the levels of PAC and PRA in T2DM group were higher than those in NGT group. The correlation coefficients were 0.245 (P 0.01) and 0.143% (P 0.05). The results of logistic regression showed that the increase of BMI and PAC were risk factors of insulin resistance. The OR values of CI: 3.30 / 21.12P0.001 and 3.570-95 CI: 1.01and 11.77-P0.05respectively were 8.596 ~ 95% (P 0.001). Conclusion the elevated levels of PAC and PRA in patients with T2DM are independent risk factors of insulin resistance compared with those in patients with NGT.
【作者单位】：潮州市中心医院内分泌科;
【基金】：潮州市卫生和计划生育局科研项目(编号:潮卫科研201605)
【分类号】：R587.1

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