甘精胰岛素对比预混胰岛素治疗2型糖尿病疗效与安全性的Meta分析

发布时间：2018-03-16 17:49

本文选题：甘精胰岛素　切入点：预混胰岛素　出处：《中国药房》2016年03期 　论文类型：期刊论文

【摘要】：目的:系统评价甘精胰岛素对比预混胰岛素治疗2型糖尿病的疗效与安全性,以为临床提供循证参考。方法:计算机检索Pub Med、相关期刊论文、万方数据库和中文科技期刊数据库,收集甘精胰岛素(试验组)对比预混胰岛素(对照组)治疗2型糖尿病疗效与安全性的随机对照试验(RCT),对符合纳入标准的临床研究进行资料提取,并采用改良后的Jadad量表进行质量评价,采用Rev Man 5.0统计软件进行Meta分析。结果:共纳入10项RCT,合计1 655例患者。Meta分析结果显示,甘精胰岛素在降低糖化血红蛋白水平[MD=-0.41,95%CI(-0.64,-0.18),P0.001]、空腹血糖水平[MD=-0.51,95%CI(-0.99,-0.02),P=0.04]方面均优于预混胰岛素,两组比较差异均有统计学意义,而在降低餐后2 h血糖水平[MD=-0.56,95%CI(-1.21,0.09),P=0.09]、体质量指数[MD=-0.52,95%CI(-1.52,0.48),P=0.31]方面,差异均无统计学意义;甘精胰岛素组患者的低血糖发生率[RR=0.65,95%CI(0.46,0.90),P=0.01]低于预混胰岛素组,差异有统计学意义。结论:甘精胰岛素治疗2型糖尿病的疗效与安全性优于预混胰岛素。
[Abstract]:Objective: to evaluate the efficacy and safety of insulin glargine contrast premixed insulin in the treatment of type 2 diabetes mellitus. Wanfang Database and Chinese Sci-tech Journals Database, A randomized controlled trial of insulin glargine (trial group) compared with premixed insulin (control group) in the treatment of type 2 diabetes mellitus was conducted. The modified Jadad scale was used to evaluate the quality and the Meta analysis was carried out by Rev Man 5.0. Results: ten items were included in the total of 1 655 patients. Insulin glargine was better than premixed insulin in reducing glycosylated hemoglobin level [MD-0.41-95CI-0.64U -0.18P0.001], fasting blood glucose level [MD-0.51c95CI-0.99C -0.02U P0.04]. The difference between the two groups was statistically significant, but in reducing blood glucose level at 2 h after meal [MD-0.5695CI-1.210.09], body mass index (MD-0.52CI-95CI-1.520.48P0.31), the difference between the two groups was statistically significant, and there was no significant difference between the two groups in reducing blood glucose level at 2 h after meal (MD-0.5695CI-1.21 0.09), body mass index (MD-0.52J / 95CI-1.50.48 / P0. 31). The incidence of hypoglycemia in insulin glargine group [RRX 0.65N 95] was significantly lower than that in premixed insulin group (P 0.01). Conclusion: the efficacy and safety of insulin glargine in the treatment of type 2 diabetes mellitus is better than that in premixed insulin group.
【作者单位】：解放军第175医院/厦门大学附属东南医院;福建中医药大学药学院;
【分类号】：R587.1

【相似文献】