补肾健脾方对骨质疏松性髋部骨折术后肌力与骨量的影响

发布时间：2018-03-16 21:38

本文选题：中医药　切入点：骨质疏松　出处：《福建中医药大学》2015年硕士论文　论文类型：学位论文

【摘要】：目的：观察补肾健脾方对骨质疏松性骸部骨折术后肌力与骨量的影响,探讨补肾健脾方对骨质疏松性骨折术后骨量的影响机制,为临床预防废用性骨质疏松症提供有效依据。方法：将2014年02月01日-2014年10月15日(随访时间至2015.02.01)收治的骨质疏松性股骨粗隆间骨折患者70例,随机分为对照组与实验组,对照组在骨折术后常规使用钙剂治疗,实验组在钙制剂治疗基础上加用中药补肾健脾方,通过观察肌力、骨量及生化指标的变化,采用PASW Statistics 18.0统计学软件进行统计分析。结果：能够按要求连续用药及随访者56例,实验组27例,对照组29例。肌力比较：术后3天、7天、1个月两组间肌力都无明显差异(P0.05),而术后15天实验组肌力明显大于对照组(P0.05)。实验组术后3天、7天、15天、1个月的肌力在明显逐渐增加(P0.05)；对照组术后15天肌力与术后7天无明显差异(P0.05),术后7天肌力比术后3天明显增加、术后1个月肌力比术后15天明显增加(P0.05)。骨量比较：实验组骨密度与骨矿含量在治疗前及随访时都无明显改变(P0.05),对照组骨矿含量在治疗前及随访时也无明显改变(P0.05),但是对照组在随访时骨密度值明显降低(P0.05)。生化指标比较：术前、术后1个月两组间骨碱性磷酸酶无明显差异(P0.05),术后3个月实验组比对照组高(P0.05)；实验组术后3个月比术前高(P0.05),术前与术后1个月无明显差异(P0.05)；对照组术后1个月、术后3个月都比术前低(P0.05),术后1个月与术后3个月无明显差异(P0.05)。术前、术后1个月两组间肌酐无明显差异(P0.05),术后3个月实验组比对照组高(P0.05)；实验组术后1个月与术后3个月的肌酐比术前的高(P0.05),术后3个月与术后1个月无明显差异(P0.05)；对照组术前、术后1个月、术后3个月间都无明显差异(P0.05)。结论：补肾健脾方对预防骨质疏松性骨折术后的骨密度降低具有积极意义,可以应用于辅助防治废用性骨质疏松症。
[Abstract]:Objective: to observe the effect of Bushen Jianpi recipe on muscle strength and bone mass of osteoporotic bone fracture, and to explore the mechanism of Bushen Jianpi recipe on bone mass after osteoporosis fracture. Methods: from February 1st 2014 to October 15th 2014 (follow-up period to 2015.02.01), 70 patients with osteoporotic intertrochanteric fracture of femur were randomly divided into control group and experimental group. The control group was treated with calcium after fracture and the experimental group was treated with traditional Chinese medicine Bushen Jianpi on the basis of calcium treatment. The changes of muscle strength, bone mass and biochemical indexes were observed. PASW Statistics 18.0 software was used to carry out statistical analysis. Results: 56 cases could be used continuously and followed up according to the requirements, 27 cases in the experimental group, 27 cases in the experimental group, and 27 cases in the experimental group. Comparison of muscle strength of 29 cases in the control group: there was no significant difference in muscle strength between the two groups on the 3rd day and 7th day after operation, and there was no significant difference between the two groups in one month, but the muscle strength in the experimental group was significantly larger than that in the control group on the 15th day after operation. The muscle strength of the experimental group was significantly higher than that of the control group on the 3rd day, 7th day and 15th day. In the control group, there was no significant difference in muscle strength between 15 days after operation and 7 days after operation, and the muscle strength at 7 days after operation was significantly higher than that at 3 days after operation. Comparison of bone mass: bone mineral density and bone mineral content in the experimental group did not change significantly before treatment and during follow-up, while bone mineral content in the control group did not change significantly before treatment and at follow-up. However, the BMD of the control group decreased significantly at the follow-up period (P 0.05). There was no significant difference in bone alkaline phosphatase (BALP) between the two groups at one month after operation (P 0.05), but the levels of bone alkaline phosphatase in the experimental group were higher than those in the control group at 3 months after operation, and in the experimental group at the third month after operation, and there was no significant difference between the two groups before operation and at one month after operation, and there was no significant difference between the two groups at 1 month after operation. There was no significant difference between 1 month after operation and 3 months after operation (P 0.05). There was no significant difference in creatinine between the two groups at 1 month after operation (P 0.05), but at 3 months after operation, the level of creatinine in the experimental group was higher than that in the control group (P 0.05), and the creatinine level in the experimental group was higher than that in the control group at 1 month and 3 months after operation, and there was no significant difference between the three months after operation and one month after operation (P 0.05). Conclusion: the prescription of tonifying kidney and strengthening spleen has positive significance in preventing the decrease of bone mineral density after osteoporosis fracture, and can be used to prevent and treat waste osteoporosis.
【学位授予单位】：福建中医药大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R580;R687.3

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