中国汉族老年人糖尿病与瘦素受体基因rs1137100和rs1137101多态性位点相关性

发布时间：2018-03-16 22:05

本文选题：瘦素受体　切入点：单核苷酸基因多态性　出处：《卫生研究》2017年03期 　论文类型：期刊论文

【摘要】：目的探讨汉族老年人糖尿病与瘦素受体基因rs1137100和rs1137101多态性位点(SNP)的相关性。方法采用Taqman方法检测241例汉族老年人糖尿病患者和270例汉族健康老年人的瘦素受体基因rs1137100和rs1137101基因型及等位基因频率分布状况,分析各SNP位点基因型与糖尿病的相关性,同时测定所有研究对象的血脂、血糖、血浆瘦素和胰岛素水平。结果 rs1137100位点GG、GA和AA基因型在糖尿病组和正常对照组之间的分布频率分别为73.0%、24.5%、2.5%和68.9%、28.9%和2.2%,两组之间差异无统计学意义(χ~2=1.27,P=0.53);A等位基因在两组间的分布频率分别是14.7%和16.7%,两组之间差异无统计学意义(χ~2=0.72,P=0.40)。rs1137101位点上GG、GA和AA基因型在糖尿病组和正常对照组之间的分布频率分别为77.6%、21.2%、1.2%和77.8%、21.1%、1.1%,两组之间差异无统计学意义(χ~2=0.02,P=0.99);A等位基因在两组间的分布频率分别是11.8%和11.7%,两组之间差异无统计学意义(χ~2=0.01,P=0.94)。Logistic回归分析结果表明,与GG型研究对象相比,rs1137100位点GA型、AA型研究对象发生糖尿病的风险相似,OR值分别为1.06(95%CI 0.34~3.34)和0.80(95%CI 0.54~1.19);在rs1137101位点上,与GG型研究对象相比,GA型、AA型研究对象发生糖尿病的风险相似,OR值分别为1.12(95%CI 0.22~5.63)和1.01(95%CI 0.66~1.54)。结论瘦素受体基因rs1137100和rs1137101位点的变异与汉族老年人糖尿病没有明显的相关性。
[Abstract]:Objective to investigate the relationship between leptin receptor gene (rs1137100) and leptin receptor gene polymorphism (rs1137101) in the elderly of Han nationality. Methods the leptin receptor gene was detected by Taqman in 241 elderly patients with diabetes and 270 healthy controls. Because of the frequency distribution of rs1137100 and rs1137101 genotypes and alleles, The relationship between SNP locus genotypes and diabetes mellitus was analyzed, and blood lipids and blood glucose were measured in all subjects. Results the distribution frequency of GGG GA-GA and AA genotype at rs1137100 locus between diabetic group and normal control group was 73.0% and 68.9%, respectively. There was no significant difference between the two groups (蠂 ~ (2 +) ~ (1.27) P ~ (0.53A) allele) in plasma leptin and insulin (P < 0.05). The distribution frequency of GGG GA-GA and AA genotype at rs1137100 locus in diabetic group and normal control group were 73.0% and 68.9% and 28.9% and 2.2%, respectively. There was no significant difference between the two groups. There was no significant difference between the two groups (蠂 ~ (2) 0.72 ~ (2)) P ~ (0.40). Rs1137101. The distribution frequencies of GGGGGA and AA genotype in diabetic group and normal control group were 77.6% and 77.821.21%, respectively. There was no significant difference between the two groups (蠂 ~ (2) ~ (2) 0. 02) P ~ (0.99A). The distribution frequency of alleles in the two groups was 11.8% and 11.70.There was no significant difference between the two groups (蠂 ~ 2 / 0. 01 ~ 0. 01 P 0. 94 ~ 0. 94) logistic regression analysis showed that there was no significant difference between the two groups. Compared with the GG study subjects, the OR values of risk of diabetes were 1.0695 CI 0.343.34 and 0.8095CI 0.541.19 in GA type AA subjects, respectively. Compared with the GG study subjects, the OR values of the patients with GA type AA were 1.1295 CI 0.225.63) and 1.0195% CI 0.661.54 respectively. Conclusion there is no significant correlation between the variation of rs1137100 and rs1137101 loci of leptin receptor gene and diabetes in the elderly of Han nationality.
【作者单位】：中国疾病预防控制中心营养与健康所国家卫生计生委微量元素营养重点实验室;
【基金】：国家自然科学基金(No.30671750)
【分类号】：R587.1

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