CXCL16与糖尿病足病的相关性探讨

发布时间：2018-03-17 03:24

本文选题：CXCL16　切入点：糖尿病足病　出处：《华北理工大学》2015年硕士论文　论文类型：学位论文

【摘要】：目的CXCL16是近年新发现的趋化因子,它与糖尿病足病的关系尚未见报道。本试验通过检测糖尿病足病患者血清CXCL16浓度变化,旨在探讨血清分泌型CXCL16与糖尿病足病的相关性。方法1以2013年1月至2014年12月在华北理工大学附属开滦总医院内分泌科住院的164例糖尿病患者作为受试对象,其中以90例糖尿病足病患者作为病例组,以74例单纯糖尿病患者作为对照组。采用酶联免疫吸附双抗体夹心法测定病例组和对照组血清CXCL16的浓度。记录受试对象的一般临床资料并比较两组间一般临床资料及血清CXCL16水平的差异。以高CXCL16水平作为暴露因素,利用四格表及OR值分析高CXCL16水平与糖尿病足病有无关联以及关联强度的大小。采用多因素Logistic逐步回归分析法探讨糖尿病足病的影响因素。2将病例组患者按是否存在足部缺血分为缺血组和非缺血组,采用相同的方法分析CXCL16与缺血性糖尿病足病的关系。结果1病例组血清CXCL16水平明显高于对照组(P0.01)。糖尿病患者血清CXCL16浓度在1.72μg/L以上时,患糖尿病足病的危险性是CXCL16在1.72μg/L以下患者的4.39倍。以是否患糖尿病足病为因变量,以病例组和对照组两组间差异具有显著性的指标为自变量做Logistic回归分析。结果显示,随着血清CXCL16和纤维蛋白原浓度的逐渐增高,糖尿病患者患糖尿病足病的危险性逐渐增大,CXCL16和纤维蛋白原是糖尿病足病的危险因素。2缺血组血清CXCL16浓度明显高于非缺血组(P0.01)。糖尿病足病患者血清CXCL16浓度在2.04μg/L以上时,患缺血性糖尿病足病的危险性是CXCL16在2.04μg/L以下患者的6.09倍。以糖尿病足病是否存在足部缺血为因变量,以缺血组和非缺血组两组间具有显著差异的指标为自变量做Logistic回归分析。结果显示,随着CXCL16和纤维蛋白原浓度的逐渐增高,血红蛋白和总胆红素浓度的逐渐降低,糖尿病足病患者发生足部缺血的危险性逐渐增大,CXCL16和纤维蛋白原是缺血性糖尿病足病的危险因素,总胆红素和血红蛋白是它的保护因素。结论1血清分泌型CXCL16与糖尿病足病呈正相关,在一定程度上促进了糖尿病足病的发生和发展。2血清分泌型CXCL16与糖尿病足病足部缺血程度呈正相关。
[Abstract]:Objective CXCL16 is a newly discovered chemokine in recent years. The relationship between CXCL16 and diabetic foot disease has not been reported. Objective to investigate the relationship between serum secretory CXCL16 and diabetic foot disease. Methods 1 A total of 164 diabetic patients hospitalized in the Department of Endocrinology of Kailuan General Hospital affiliated to North China University of Technology from January 2013 to December 2014 were selected as subjects. Among them, 90 cases of diabetic foot disease were used as the case group. 74 patients with simple diabetes mellitus were used as control group. The serum CXCL16 concentration was measured by enzyme-linked immunosorbent assay (Elisa). The general clinical data of the subjects were recorded and the general clinical information was compared between the two groups. The difference of serum CXCL16 levels. High CXCL16 levels were used as exposure factors. The relationship between high CXCL16 level and diabetic foot disease and the magnitude of correlation strength were analyzed by using four case tables and OR value. The multivariate Logistic stepwise regression analysis was used to study the influencing factors of diabetic foot disease. 2. In the foot ischemia is divided into ischemic group and non-ischemic group, The relationship between CXCL16 and ischemic diabetic foot disease was analyzed by the same method. Results the level of serum CXCL16 in the first case group was significantly higher than that in the control group (P 0.01). When the serum CXCL16 concentration of diabetic patients was more than 1.72 渭 g / L. The risk of diabetic foot disease was 4.39 times higher than that of patients with CXCL16 below 1.72 渭 g / L. the Logistic regression analysis was performed with the dependent variable of diabetic foot disease and the index with significant difference between the two groups. The results showed that the risk of diabetic foot disease was less than 1.72 渭 g / L, and the risk of diabetic foot disease was 4.39 times higher than that of patients with CXCL16 below 1.72 渭 g / L. With the increase of serum CXCL16 and fibrinogen concentration, CXCL16 and fibrinogen were the risk factors of diabetic foot disease. 2 the serum CXCL16 concentration in ischemic group was significantly higher than that in non-ischemic group (P 0.01). When the serum CXCL16 concentration of diabetic foot disease was above 2.04 渭 g / L. The risk of ischemic diabetic foot disease was 6.09 times higher than that of patients with CXCL16 below 2.04 渭 g / L. The results of Logistic regression analysis showed that the concentration of hemoglobin and total bilirubin decreased with the increase of CXCL16 and fibrinogen concentration. CXCL16 and fibrinogen are the risk factors of diabetic foot disease. Total bilirubin and hemoglobin were the protective factors. Conclusion 1 Serum secretory CXCL16 is positively correlated with diabetic foot disease. To some extent, it promoted the occurrence and development of diabetic foot disease. 2 Serum secretory CXCL16 was positively correlated with the degree of diabetic foot ischemia.
【学位授予单位】：华北理工大学
【学位级别】：硕士
【学位授予年份】：2015
【分类号】：R587.2

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