SLE患者外周血滤泡辅助性T细胞的检测及其临床意义

发布时间：2018-03-20 02:09

本文选题：红斑狼疮　切入点：系统性　出处：《重庆医学》2016年05期 　论文类型：期刊论文

【摘要】：目的探讨滤泡辅助性T细胞(Tfh)在系统性红斑狼疮(SLE)患者外周血的比例及其临床意义。方法收集60例SLE患者(SLE组)及60例健康体检者(对照组)外周血,采用流式细胞术方法检测CXCR5+ICOS+的CD4+T细胞(即Tfh细胞)的比例,并分析Tfh细胞比例与患者疾病活动度及自身抗体的相关性。结果 SLE组患者外周血Tfh细胞比例明显高于对照组(t=5.830,P0.01),且SLE活动组明显高于SLE稳定组(t=7.313,P0.01),但狼疮肾炎组患者Tfh比例与无肾炎狼疮组比较,差异无统计学意义(t=0.986,P=0.328)。SLE患者外周血Tfh细胞比例与疾病活动度、血清总IgG、抗核抗体滴度及抗dsDNA均呈正相关(P0.05)。结论 SLE患者外周血Tfh细胞的比例升高可能与患者疾病的发生及发展有关。
[Abstract]:Objective to investigate the proportion of peripheral blood follicular helper T cells (TFH) in patients with systemic lupus erythematosus (SLE) and its clinical significance. Methods Peripheral blood samples were collected from 60 patients with SLE and 60 healthy controls. The percentage of CD4 T cells (Tfh cells) of CXCR5 ICOS was detected by flow cytometry. Results the percentage of Tfh cells in peripheral blood in SLE group was significantly higher than that in control group (5.830) P0.01, and that in SLE active group was significantly higher than that in SLE stable group, but the incidence of lupus nephritis was higher than that in lupus nephritis group. The proportion of Tfh in patients without lupus nephritis was higher than that in patients without lupus nephritis. There was no significant difference in the percentage of Tfh cells and disease activity in peripheral blood of patients with SLE. Serum total IgG, antinuclear antibody titer and anti dsDNA were positively correlated with P0.05.Conclusion the increase in the proportion of Tfh cells in peripheral blood of patients with SLE may be related to the occurrence and development of the disease.
【作者单位】：云南省第一人民医院风湿免疫科;
【分类号】：R593.241

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