抗性淀粉对2型糖尿病代谢的影响:系统评价和Meta分析

发布时间：2018-03-20 13:48

本文选题：抗性淀粉　切入点：糖尿病　出处：《重庆医学》2017年36期 　论文类型：期刊论文

【摘要】：目的探讨抗性淀粉(RS)对2型糖尿病(T2DM)代谢的影响。方法分别在Pubmed、Ovid、Embase、The Cochrane Library数据库中检索RS饮食干预2型糖尿病的随机对照研究的文献,检索时间均至2016年6月21日。文献质量采用Cochrane协作网推荐的偏倚风险评估工具进行评估。相关数据用Stata12.0软件进行整合、分析。结果共检索文献909篇,其中6篇符合纳入标准,共纳入研究对象308例。研究均显示RS干预后T2DM患者的空腹血糖显著降低。有4项研究检测了餐后血糖,并均认为RS干预后T2DM患者的餐后血糖显著降低(依次为P=0.023,P=0.010,P0.05,P=0.045)。3项研究报道了空腹总胆固醇(TC)及三酰甘油(TG)相关数据,但研究结果分歧较大。Gargari等的研究认为,与对照组相比RS组高密度脂蛋白胆固醇(HDL-C)明显升高(P0.05),低密度脂蛋白胆固醇(LDL-C)差异无统计学意义(P0.05)。而Bodinham等的研究中两组间HDL-C和LDL-C差异均无统计学意义(P0.05)。Gargari等及Bodinham等的研究均认为与对照组比较,RS组TNF-α明显降低(依次为P0.05,P=0.013),而前者认为RS组IL-6也降低的,后者则认为两组IL-6差异无统计学意义(P0.05)。结论抗性淀粉能够提高2型糖尿病患者的胰岛素敏感性,改善糖、脂代谢紊乱。
[Abstract]:Objective to investigate the effect of resistant starch RSs on the metabolism of type 2 diabetes mellitus (T2DM). Methods the literature of randomized controlled study on RS diet intervention in type 2 diabetes mellitus was searched in the Cochrane Library database of Pubmeda Ovidbase. The retrieval time was up to June 21st 2016. The literature quality was evaluated with the bias risk assessment tool recommended by Cochrane Cooperative Network. The related data were integrated with Stata12.0 software and analyzed. A total of 308 subjects were enrolled in the study. The results showed that fasting blood glucose decreased significantly in patients with T2DM after RS intervention. Four studies measured postprandial blood glucose. It was considered that the postprandial blood glucose levels of patients with T2DM were significantly decreased after RS intervention (the order of which was P0. 023, P0. 010, P0. 05, P0. 045) and the data of fasting total cholesterol (TCC) and triglyceride (TGG) were reported. However, the results of the studies were quite different from those of Gargari et al. High density lipoprotein cholesterol (HDL-C) in RS group was significantly higher than that in control group (P 0.05), and LDL-C in low density lipoprotein cholesterol (LDL-C) was not significantly different from that in control group (P 0.05). However, there was no significant difference in HDL-C and LDL-C between the two groups in the study of Bodinham et al. The results showed that compared with the control group, TNF- 伪 in RS group was significantly lower than that in control group (P 0.05) and IL-6 in RS group was also decreased. Conclusion resistant starch can improve insulin sensitivity and improve glucose and lipid metabolism in patients with type 2 diabetes mellitus.
【作者单位】：西南医科大学附属医院内分泌科;
【分类号】：R587.1

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