白芍总苷辅助治疗系统性硬化症的临床观察

发布时间：2018-03-21 12:54

本文选题：白芍总苷　切入点：系统性硬化症　出处：《中国中西医结合杂志》2017年07期 　论文类型：期刊论文

【摘要】：目的研究白芍总苷(TGP)治疗系统性硬化症(SSc)的临床疗效和安全性。方法将50例SSc患者随机分为TGP联合西药治疗组(简称联合组)和单纯西药对照组(简称对照组),治疗24周。观察患者改良Rodnan积分、关节功能积分、齿距、双手握力、手指温度、IgG水平、24 h尿蛋白、肺弥散功能,并监测药物不良反应。结果联合组的总有效率92.0%(23/25)明显高于对照组68.0%(17/25),两组总有效率比较,差异有统计学意义(χ~2=4.5,P0.05);联合组患者的齿距、手指温度、Ig G水平、24 h尿蛋白在治疗12周后即较治疗前明显改善(P0.05,P0.01),而对照组的上述4个指标在24周后较治疗前有明显改善(P0.05,P0.01);在治疗24周后,联合组患者的齿距、手指温度、双手握力明显高于对照组,IgG水平、24 h尿蛋白明显低于对照组(P0.05,P0.01)。两组肺弥散功能的改善差异无统计学意义(P0.05)。联合组无肝功能损害(简称肝损)的发生,明显低于对照组[20%(5/25)]。结论 TGP辅助治疗SSc,较单用西药总有效率高,加快且优化24周后的疗效,降低肝损的发生率。
[Abstract]:Objective to study the clinical efficacy and safety of total glucoside of paeony (TGP) in the treatment of systemic sclerosis (SSC). Methods 50 patients with SSc were randomly divided into two groups: TGP combined with western medicine (combined group) and simple western medicine control group (control group). After 24 weeks of treatment, the modified Rodnan score was observed. The joint function score, tooth pitch, grip strength of both hands, finger temperature and IgG level of 24 h urine protein, pulmonary diffusive function, and adverse drug reactions were monitored. Results the total effective rate of the combined group was 92.0 卤23 / 25) significantly higher than that of the control group (68.0% / 25%), and the total effective rate of the two groups was higher than that of the control group, and the total effective rate of the two groups was higher than that of the control group. The difference was statistically significant (蠂 ~ (2 +) 4.5U P 0.05), and the tooth pitch of the patients in the combined group was higher than that in the control group (P < 0.05). After 12 weeks of treatment, urinary protein of 24 h was significantly improved compared with that before treatment, while the above four indexes in the control group were significantly improved after 24 weeks compared with those before treatment. After 24 weeks of treatment, the tooth pitch and finger temperature of the patients in the combined group were significantly improved. The grip strength of both hands was significantly higher than that of the control group. The 24 h urinary protein level in the control group was significantly lower than that in the control group (P 0.05 and P 0.01). There was no significant difference in the improvement of pulmonary diffusive function between the two groups (P 0.05). There was no liver function damage in the combined group. Conclusion the total effective rate of TGP adjuvant therapy is higher than that of western medicine alone. It can accelerate and optimize the curative effect after 24 weeks and reduce the incidence of liver damage.
【作者单位】：南京中医药大学第一临床医学院中西医结合临床学系;南京大学医学院附属鼓楼医院风湿免疫科;南京中医药大学第一临床医学院中医内科学系;
【基金】：国家自然科学基金面上项目(No.81473607)
【分类号】：R593.2

【相似文献】